Table 4. Genes identified through analysis with 22Rv1 cells that showed significant increased methylation in Gleason score 8 vs Gleason score 6 prostate cancer tumors.
| Gene Symbol | Gene Name | CpG Location | Fold Change | p- value |
|---|---|---|---|---|
| NRIP3 | nuclear receptor interacting protein 3 | Promoter | 2.023 | <0.001 |
| B4GALNT1 | beta-1,4-N-acetyl-galactosaminyl transferase 1 | Intragenic | 2.19 | <0.001 |
| ACTA1 | actin, alpha 1, skeletal muscle | Intragenic | 3.026 | 0.0007 |
| TFAP2B | transcription factor AP-2 beta (activating enhancer binding protein 2 beta) | Intragenic | 2.219 | 0.0039 |
| TGFB2 | transforming growth factor, beta 2 | Intragenic | 1.846 | 0.0048 |
| TBX2 | T-box 2 | Intragenic | 1.558 | 0.0121 |
| TESC | tescalcin | Intragenic | 1.545 | 0.0191 |
| TRAF3 | TNF receptor-associated factor 3 | Intragenic | 1.804 | 0.0205 |
| DSC3 | desmocollin 3 | Intragenic | 1.508 | 0.0481 |