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Covalent poisons do not enhance DNA cleavage mediated by the catalytic core of human topoisomerase IIα. Effects of benzoquinone (left) and thymoquinone (right) on DNA cleavage mediated by wild-type human topoisomerase IIα (black), the catalytic core (red), and hTop2αΔ1175 (blue) are shown. Error bars represent the standard deviation of at least three independent experiments.
