Figure 2.

Secondary structure and aggregation propensities of the RTX domain. The sequence of the RTX domain from P. aeruginosa alkaline protease is shown. Secondary structure elements are shown above the sequence with β-structure indicated by bars and α-structure indicated by curves. Sequences of five or more amino acids predicted to form amyloid structure are indicated as saw teeth below the protein sequence. Asterisks indicate the diglycine motifs present in the RTX nonapeptide repeats. The indicated residue numbering and secondary structure assignment are consistent with the X-ray structures from Protein Data Bank entries 1KAP and 1JIW.