Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1976 Jan;13(1):31–35. doi: 10.1128/iai.13.1.31-35.1976

T and CR+ lymphocyte profile in leprosy and the effect of treatment.

R Sher, G Holm, S H Kok, H J Koornhof, A Glover
PMCID: PMC420573  PMID: 1082444

Abstract

Thymus-derived lymphocytes (T lymphocytes) and complement receptor-bearing lymphocytes (CR+ lymphocytes) were estimated by using erythrocyte rosettes and erythrocyte-antibody-complement rosettes as markers in untreated lepromatous and untreated tuberculoid patients and in healthy controls. Treated lepromatous cases were also investigated. Ten cases of untreated lepromatous patients were reassessed 6 months or more after therapy commenced. A significant decrease in both percentages and absolute numbers of CR+ cells in the untreated lepromatous leprosy subjects was observed. This decrease showed a return to normal levels after treatment. The percentage of T cells in the untreated lepromatous cases was normal; however, the absolute numbers of T cells and the total lymphocyte count showed a significant decrease. After therapy, the T cell population was unchanged but the total number of lymphocytes increased significantly with treatment. The absolute number of T and CR+ cells was significantly less in the untreated than in the treated lepromatous patients.

Full text

PDF
31

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boyle W. An extension of the 51Cr-release assay for the estimation of mouse cytotoxins. Transplantation. 1968 Sep;6(6):761–764. doi: 10.1097/00007890-196809000-00002. [DOI] [PubMed] [Google Scholar]
  2. Drutz D. J., Chen T. S., Lu W. H. The continuous bacteremia of lepromatous leprosy. N Engl J Med. 1972 Jul 27;287(4):159–164. doi: 10.1056/NEJM197207272870402. [DOI] [PubMed] [Google Scholar]
  3. Dwyer J. M., Bullock W. E., Fields J. P. Disturbance of the blood T:B lymphocyte ratio in lepromatous leprosy. Clinical and immunologic correlations. N Engl J Med. 1973 May 17;288(20):1036–1039. doi: 10.1056/NEJM197305172882002. [DOI] [PubMed] [Google Scholar]
  4. Gajl-Peczalska K. J., Lim S. D., Jacobson R. R., Good R. A. B lymphocytes in lepromatous leprosy. N Engl J Med. 1973 May 17;288(20):1033–1035. doi: 10.1056/NEJM197305172882001. [DOI] [PubMed] [Google Scholar]
  5. Godal T. Cellular immune defect in lepromatous leprosy. Ethiop Med J. 1973 Apr;11(2):190–193. [PubMed] [Google Scholar]
  6. Han S. H., Weiser R. S., Lin Y. C. Transformation of leprous lymphocytes by leprolin, tuberculin and phytohemagglutinin. Int J Lepr Other Mycobact Dis. 1971 Oct-Dec;39(4):789–795. [PubMed] [Google Scholar]
  7. Jondal M., Holm G., Wigzell H. Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. J Exp Med. 1972 Aug 1;136(2):207–215. doi: 10.1084/jem.136.2.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lim S. D., Kiszkiss D. F., Jacobson R. R., Choi Y. S., Good R. A. Thymus-dependent lymphocytes of peripheral blood in leprosy patients. Infect Immun. 1974 Feb;9(2):394–399. doi: 10.1128/iai.9.2.394-399.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Mellstedt H., Holm G. In vitro studies of lymphocytes from patients with plasma cell myeloma. I. Stimulation by mitogens and cytotoxic activities. Clin Exp Immunol. 1973 Nov;15(3):309–320. [PMC free article] [PubMed] [Google Scholar]
  10. Moran C. J., Ryder G., Turk J. L., Waters M. F. Evidence for circulating immune complexes in lepromatous leprosy. Lancet. 1972 Sep 16;2(7777):572–573. doi: 10.1016/s0140-6736(72)91962-9. [DOI] [PubMed] [Google Scholar]
  12. Playfair J. H. The role of antibody in T-cell responses. Clin Exp Immunol. 1974 May;17(1):1–18. [PMC free article] [PubMed] [Google Scholar]
  13. Ridley D. S., Jopling W. H. Classification of leprosy according to immunity. A five-group system. Int J Lepr Other Mycobact Dis. 1966 Jul-Sep;34(3):255–273. [PubMed] [Google Scholar]
  14. Rodriguez Paradisi E., de Bonaparte Y. P., Morgenfeld M. C. Blasts in lepromatous leprosy. Lancet. 1968 Feb 10;1(7537):308–309. doi: 10.1016/s0140-6736(68)90173-6. [DOI] [PubMed] [Google Scholar]
  15. Rojas-Espinosa O., Mendez-Navarrete I., Estrada-Parra S. Presence of C1q-reactive immune complexes in patients with leprosy. Clin Exp Immunol. 1972 Oct;12(2):215–223. [PMC free article] [PubMed] [Google Scholar]
  16. Turk J. L., Bryceson A. D. Immunological phenomena in leprosy and related diseases. Adv Immunol. 1971;13:209–266. doi: 10.1016/s0065-2776(08)60185-6. [DOI] [PubMed] [Google Scholar]
  17. Turk J. L., Waters M. F. Cell-mediated immunity in patients with leprosy. Lancet. 1969 Aug 2;2(7614):243–246. doi: 10.1016/s0140-6736(69)90009-9. [DOI] [PubMed] [Google Scholar]
  18. Turk J. L., Waters M. F. Immunological significance of changes in lymph nodes across the leprosy spectrum. Clin Exp Immunol. 1971 Mar;8(3):363–376. [PMC free article] [PubMed] [Google Scholar]
  19. Waldorf D. S., Sheagren J. N., Trautman J. R., Block J. B. Impaired delayed hypersensitivity in patients with lepromatous leprosy. Lancet. 1966 Oct 8;2(7467):773–776. doi: 10.1016/s0140-6736(66)90366-7. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES