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. 1976 Jan;13(1):63–68. doi: 10.1128/iai.13.1.63-68.1976

Comparative production of interferon by explanted lymphoreticular tissue and alveolar macrophages from rabbits and humans.

F B Kolot, S Baron, H Yeager Jr, S L Schwartz
PMCID: PMC420577  PMID: 1248877

Abstract

Studies were undertaken to compare interferon production among a variety of lymphoreticular cells, with emphasis on the alveolar macrophage. Explanted cells from rabbit lung, spleen, peritoneum, bone marrow, and blood produced interferon in varying amounts in response to six of the seven viruses studied. The various lymphoreticular tissues responded differently to a single interferon-inducing virus, and each tissue produced varying amounts of interferon when stimulated by different viruses. In addition, glass-adherent rabbit alveolar macrophages produced more interferon than did the nonadherent subpopulation. Human blood and lung cells produced much less interferon than did the equivalent rabbit cells under similar conditions of stimulation. It appeared that interferon production may have been controlled by several variables, including the species, the type of inducer, and the type of tissue and cell.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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