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. 1976 Jan;13(1):78–83. doi: 10.1128/iai.13.1.78-83.1976

Effect of viral and bacterial pneumonias on cell-mediated immunity in humans.

C A Kauffman, C C Linnemann Jr, G M Schiff, J P Phair
PMCID: PMC420579  PMID: 1082445

Abstract

Cell-mediated immunity (CMI) was assessed during infection and after convalescence in 12 patients with influenza pneumonia and 10 patients with bacterial pneumonia. The patients with influenza pneumonia had a marked impairment of skin test reactivity, and their lymphocytes showed a diminished response to phytohemagglutinin and streptokinase-streptodornase stimulation in vitro. Suppression of CMI was related to the severity of the pneumonia. Patients with bacterial pneumonia showed as great a suppression of the response to phytohemagglutinin and streptokinase-streptodornase as the patients with viral pneumonia. All parameters of CMI returned to normal in both groups after convalescence. The depression of CMI could not be related to a decrease in the number of thymus-derived lymphocytes or to serum-suppressive factors in these patients.

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Selected References

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