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. 1976 Jan;13(1):247–251. doi: 10.1128/iai.13.1.247-251.1976

Response of Neisseria gonorrhoeae to Bdellovibrio species.

D J Drutz
PMCID: PMC420601  PMID: 814101

Abstract

Bdellovibrio species are small, highly motile bacteria that are predators upon other bacteria in nature. Bdellovibrios attach to, penetrate, replicate within, and destroy prey that share the general characteristic of gram negativity. The lipopolysaccharide moiety of the cell membrane of target microorganisms appears to contain the principal receptor site for bdellovibrio attachment. Since gonococci also contain lipopolysaccharide that is similar in many respects to that contained within gram-negative rods, studies were conducted to determine the extent of gonococcal interaction with a variety of bdellovibrio species. Despite transient attachment, penetration of gonococci by bdellovibrios never occurred. Failure of bdellovibrio parasitization was unrelated to gonococcal species, colony type, piliation, penicillin susceptibility, or virulence as influenced by passage in embryonated eggs. In experiments involving mixtures of gonococci and more typical gram-negative bacillary prey, the latter were always attacked by bdellovibrios, whereas the former were ignored. Despite evidence for similarities between gonococcal and gram-negative bacillary lipopolysaccharides, resemblances do not extend to the point where gonococci are susceptible to bdellovibrio parasitization.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Apicella M. A. Antigenically distinct populations of Neisseria gonorrhoeae: isolation and characterization of the responsible determinants. J Infect Dis. 1974 Dec;130(6):619–625. doi: 10.1093/infdis/130.6.619. [DOI] [PubMed] [Google Scholar]
  2. Hespell R. B., Rosson R. A., Thomashow M. F., Rittenberg S. C. Respiration of Bdellovibrio bacteriovorus strain 109J and its energy substrates for intraperiplasmic growth. J Bacteriol. 1973 Mar;113(3):1280–1288. doi: 10.1128/jb.113.3.1280-1288.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Houston K. J., Aldridge K. E., Magee L. A. The effect of R antigen on the attachment of Bdellovibrio bacteriovorus to Salmonella typhimurium. Acta Microbiol Pol A. 1974;6(3):253–255. [PubMed] [Google Scholar]
  4. Johnston K. H., Gotschlich E. C. Isolation and characterization of the outer membrane of Neisseria gonorrhoeae. J Bacteriol. 1974 Jul;119(1):250–257. doi: 10.1128/jb.119.1.250-257.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. KELLOGG D. S., Jr, PEACOCK W. L., Jr, DEACON W. E., BROWN L., PIRKLE D. I. NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION. J Bacteriol. 1963 Jun;85:1274–1279. doi: 10.1128/jb.85.6.1274-1279.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Maeland J. A. Antigenic properties of various preparations of Neisseria gonorrhoeae endotoxin. Acta Pathol Microbiol Scand. 1968;73(3):413–422. doi: 10.1111/j.1699-0463.1968.tb04610.x. [DOI] [PubMed] [Google Scholar]
  7. Maeland J. A., Kristoffersen T., Hofstad T. Immunochemical investigations on neisseria gonorrhoeae endotoxin. 2. Serological multispecificity and other properties of phenol-water preparations. Acta Pathol Microbiol Scand B Microbiol Immunol. 1971;79(2):233–238. [PubMed] [Google Scholar]
  8. Maeland J. A., Kristoffersen T. Immunochemical investigations on Neisseria gonorrhoeae endotoxin. 1. Characterization of phenol-water extracted endotoxin and comparison with aqueous ether preparations. Acta Pathol Microbiol Scand B Microbiol Immunol. 1971;79(2):226–232. [PubMed] [Google Scholar]
  9. Maness M. J., Sparling P. F. Multiple antibiotic resistance due to a single mutation in Neisseria gonorrhoeae. J Infect Dis. 1973 Sep;128(3):321–330. doi: 10.1093/infdis/128.3.321. [DOI] [PubMed] [Google Scholar]
  10. REYN A., BENTZON M. W., ERICSSON H. Comparative investigations of the sensitivity of N. gonorrhoeae to penicillin. Acta Pathol Microbiol Scand. 1963;57:235–255. doi: 10.1111/j.1699-0463.1963.tb03447.x. [DOI] [PubMed] [Google Scholar]
  11. Reyn A. Recent developments in the laboratory diagnosis of gonococcal infections. Bull World Health Organ. 1969;40(2):245–255. [PMC free article] [PubMed] [Google Scholar]
  12. Rittenberg S. C., Shilo M. Early host damage in the infection cycle of Bdellovibrio bacteriovorus. J Bacteriol. 1970 Apr;102(1):149–160. doi: 10.1128/jb.102.1.149-160.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. STOLP H., STARR M. P. BDELLOVIBRIO BACTERIOVORUS GEN. ET SP. N., A PREDATORY, ECTOPARASITIC, AND BACTERIOLYTIC MICROORGANISM. Antonie Van Leeuwenhoek. 1963;29:217–248. doi: 10.1007/BF02046064. [DOI] [PubMed] [Google Scholar]
  14. Shilo M. Morphological and physiological aspects of the interaction of Bdellovibrio with host bacteria. Curr Top Microbiol Immunol. 1969;50:174–204. doi: 10.1007/978-3-642-46169-9_6. [DOI] [PubMed] [Google Scholar]
  15. Snellen J. E., Starr M. P. Ultrastructural aspects of localized membrane damage in Spirillum serpens VHL early in its association with Bdellovibrio bacteriovorus 109D. Arch Microbiol. 1974;100(3):179–195. doi: 10.1007/BF00446316. [DOI] [PubMed] [Google Scholar]
  16. Starr M. P., Seidler R. J. The Bdellovibros. Annu Rev Microbiol. 1971;25:649–678. doi: 10.1146/annurev.mi.25.100171.003245. [DOI] [PubMed] [Google Scholar]
  17. Swanson J., Kraus S. J., Gotschlich E. C. Studies on gonococcus infection. I. Pili and zones of adhesion: their relation to gonococcal growth patterns. J Exp Med. 1971 Oct 1;134(4):886–906. doi: 10.1084/jem.134.4.886. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Varon M., Shil M. Interacton of Bdellovibrio bacteriovorus and host bacteria. I. Kinetic studies of attachment and invasion of Escherichia coli B by Bdellovibrio bacteriovorus. J Bacteriol. 1968 Mar;95(3):744–753. doi: 10.1128/jb.95.3.744-753.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Varon M., Shilo M. Attachment of Bdellovibrio bacteriovorus to cell wall mutants of Salmonella spp. and Escherichia coli. J Bacteriol. 1969 Feb;97(2):977–979. doi: 10.1128/jb.97.2.977-979.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. WALSH M. J., BROWN B. C., BROWN L., PIRKLE C. I. USE OF THE CHICK EMBRYO IN MAINTAINING AND RESTORING VIRULENCE OF NEISSERIA GONORRHOEAE. J Bacteriol. 1963 Sep;86:478–481. doi: 10.1128/jb.86.3.478-481.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Wolf-Watz H., Elmros T., Normark S., Bloom G. D. Cell envelope of Neisseria gonorrhoeae: outer membrane and peptidoglycan composition of penicillin-sensitive and-resistant strains. Infect Immun. 1975 Jun;11(6):1332–1341. doi: 10.1128/iai.11.6.1332-1341.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]

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