Abstract
The hemolytic activity of staphylococcal alpha-toxin is inhibited by an N-acetylglucosamine-containing ganglioside (GlcNAc-ganglioside) but not by any of the related glycolipids. The GlcNAc-ganglioside also is precipitated with the toxin by a gel-diffusion technique. It is postulated that GlcNAc-ganglioside may be the membrane receptor for the alpha-toxin.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ando S., Kon K., Isobe M., Yamakawa T. Structural study on tetraglycosyl ceremide and gangliosides isolated from human red blood cells. J Biochem. 1973 Apr;73(4):893–895. doi: 10.1093/oxfordjournals.jbchem.a130152. [DOI] [PubMed] [Google Scholar]
- BERNHEIMER A. W., SCHWARTZ L. L. Isolation and composition of staphylococcal alpha toxin. J Gen Microbiol. 1963 Mar;30:455–468. doi: 10.1099/00221287-30-3-455. [DOI] [PubMed] [Google Scholar]
- Holmgren J., Lönnroth I., Svennerholm L. Tissue receptor for cholera exotoxin: postulated structure from studies with GM1 ganglioside and related glycolipids. Infect Immun. 1973 Aug;8(2):208–214. doi: 10.1128/iai.8.2.208-214.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KLENK E., PADBERG G. [On the gangliosides of horse erythrocytes]. Hoppe Seylers Z Physiol Chem. 1962 May 4;327:249–255. doi: 10.1515/bchm2.1962.327.1.249. [DOI] [PubMed] [Google Scholar]
- Kato I., Sakoda K., Saito M., Suzuki Y., Watanabe M. Inhibitory effect of flavin mononucleotide on the hemolysis of rabbit erythrocytes by staphylococcal alpha-toxin. Infect Immun. 1975 Sep;12(3):696–697. doi: 10.1128/iai.12.3.696-697.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kato I., Watanuki A. Effect of diphtheria toxin on lysosome activity in leukocytes and Ehrlich ascites tumor cells. Jpn J Exp Med. 1970 Apr;40(2):87–100. [PubMed] [Google Scholar]
- Li Y. T., Månsson J. E., Vanier M. T., Svennerholm L. Structure of the major glucosamine-containing ganglioside of human tissues. J Biol Chem. 1973 Apr 10;248(7):2634–2636. [PubMed] [Google Scholar]
- Naiki M., Kamimura H., Taketomi T., Ichikawa R. Chemical, physico-chemical and morphological properties of Forssman hapten purified from caprine erythrocytes. Jpn J Exp Med. 1972 Jun;42(3):205–219. [PubMed] [Google Scholar]
- Naiki M., Marcus D. M. Human erythrocyte P and Pk blood group antigens: identification as glycosphingolipids. Biochem Biophys Res Commun. 1974 Oct 8;60(3):1105–1111. doi: 10.1016/0006-291x(74)90426-4. [DOI] [PubMed] [Google Scholar]
- Naiki M., Marcus D. M., Ledeen R. Properties of antisera to ganglioside GM1 and asialo GM1. J Immunol. 1974 Jul;113(1):84–93. [PubMed] [Google Scholar]
- Siddiqui B., Hakomori S. A ceramide tetrasaccharide of human erythrocyte membrane reacting with anti-type XIV pneumococcal polysaccharide antiserum. Biochim Biophys Acta. 1973 Dec 13;330(2):147–155. doi: 10.1016/0005-2736(73)90219-8. [DOI] [PubMed] [Google Scholar]
- VAN HEYNINGEN W. E. The fixation of tetanus toxin, strychnine, serotonin and other substances by ganglioside. J Gen Microbiol. 1963 Jun;31:375–387. doi: 10.1099/00221287-31-3-375. [DOI] [PubMed] [Google Scholar]
- Van Heyningen W. E., Carpenter C. C., Pierce N. F., Greenough W. B., 3rd Deactivation of cholera toxin by ganglioside. J Infect Dis. 1971 Oct;124(4):415–418. doi: 10.1093/infdis/124.4.415. [DOI] [PubMed] [Google Scholar]
- Watanabe M., Kato I. Purification and some properties of staphylococcal alpha-toxin. Jpn J Exp Med. 1974 Apr;44(2):165–178. [PubMed] [Google Scholar]
- Wiegandt H., Bücking H. W. Carbohydrate components of extraneuronal gangliosides from bovine and human spleen, and bovine kidney. Eur J Biochem. 1970 Aug;15(2):287–292. doi: 10.1111/j.1432-1033.1970.tb01006.x. [DOI] [PubMed] [Google Scholar]