Abstract
Treatment of bacterial lipopolysaccharides (endotoxins) isolated from Salmonella minnesota R595 or purified lipid A with the antibiotic polymyxin B has been demonstrated to abrogate the ability of these molecules to activate serum complement. The inhibition is a function of the ratio of polymyxin B to lipopolysaccharide.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cochrane C. G., Müller-Eberhard H. J., Aikin B. S. Depletion of plasma complement in vivo by a protein of cobra venom: its effect on various immunologic reactions. J Immunol. 1970 Jul;105(1):55–69. [PubMed] [Google Scholar]
- Corrigan J. J., Jr, Bell B. M. Endotoxin-induced intravascular coagulation: prevention with polymyxin B sulfate. J Lab Clin Med. 1971 May;77(5):802–810. [PubMed] [Google Scholar]
- GILBERT V. E., BRAUDE A. I. Reduction of serum complement in rabbits after injection of endotoxin. J Exp Med. 1962 Oct 1;116:477–490. doi: 10.1084/jem.116.4.477. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Galanos C., Lüderitz O., Westphal O. A new method for the extraction of R lipopolysaccharides. Eur J Biochem. 1969 Jun;9(2):245–249. doi: 10.1111/j.1432-1033.1969.tb00601.x. [DOI] [PubMed] [Google Scholar]
- Galanos C., Rietschel E. T., Lüderitz O., Westphal O. Interaction of lipopolysaccharides and lipid A with complement. Eur J Biochem. 1971 Mar 1;19(1):143–152. doi: 10.1111/j.1432-1033.1971.tb01298.x. [DOI] [PubMed] [Google Scholar]
- Garner R., Chater B. V., Brown D. L. The role of complement in endotoxin shock and disseminated intravascular coagulation: experimental observations in the dog. Br J Haematol. 1974 Nov;28(3):393–401. doi: 10.1111/j.1365-2141.1974.tb00820.x. [DOI] [PubMed] [Google Scholar]
- Jacobs M. D., Morrison D. C. Dissociation between mitogenicity and immunogenicity of TNP-lipopolysaccharide, a T-independent antigen. J Exp Med. 1975 Jun 1;141(6):1453–1458. doi: 10.1084/jem.141.6.1453. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mergenhagen S. E., Gewurz H., Bladen H. A., Nowotny A., Kasai N., Lüderitz O. Interactions of the complement system with endotoxins from a Salmonella minnesota mutant deficient in O-polysaccharide and heptose. J Immunol. 1968 Jan;100(1):227–229. [PubMed] [Google Scholar]
- Morrison D. C., Leive L. Fractions of lipopolysaccharide from Escherichia coli O111:B4 prepared by two extraction procedures. J Biol Chem. 1975 Apr 25;250(8):2911–2919. [PubMed] [Google Scholar]
- NETER E., GORZYNSKI E. A., WESTPHAL O., LUDERITZ O. The effects of antibiotics on enterobacterial lipopolysaccharides (endotoxins), hemagglutination and hemolysis. J Immunol. 1958 Jan;80(1):66–72. [PubMed] [Google Scholar]
- Palmer J. D., Rifkind D. Neutralization of the hemodynamic effects of endotoxin by polymyxin B. Surg Gynecol Obstet. 1974 May;138(5):755–759. [PubMed] [Google Scholar]
- Rifkind D., Hill R. B., Jr Neutralization of the Shwartzman reactions by polymyxins B. J Immunol. 1967 Sep;99(3):564–569. [PubMed] [Google Scholar]
- Rifkind D., Palmer J. D. Neutralization of endotoxin toxicity in chick embryos by antibiotics. J Bacteriol. 1966 Oct;92(4):815–819. doi: 10.1128/jb.92.4.815-819.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rifkind D. Prevention by polymyxin B of endotoxin lethality in mice. J Bacteriol. 1967 Apr;93(4):1463–1464. doi: 10.1128/jb.93.4.1463-1464.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Snyderman R., Pike M. C. Interaction of complex polysaccharides with the complement system: effect of calcium depletion on terminal component consumption. Infect Immun. 1975 Feb;11(2):273–279. doi: 10.1128/iai.11.2.273-279.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
