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. 1976 Feb;13(2):464–469. doi: 10.1128/iai.13.2.464-469.1976

Suppression of cell-mediated immunity after infection with attenuated rubella virus.

R Ganguly, C L Cusumano, R H Waldman
PMCID: PMC420634  PMID: 770329

Abstract

The effects of attenuated rubella virus infection upon cell-mediated immunity of human volunteers were studied. The volunteers received the vaccine either by nose drops or by the subcutaneous route. Changes in cell-mediated immunity in terms of delayed cutaneous sensitivity to recall antigens, phytohemagglutination stimulation, and spontaneous migration inhibitory factor-like activity were studied at various time periods after infection. Spontaneous migration inhibitory factor-like activity was studied on supernatants of the lymphocytes obtained from the volunteers and incubated for 72 h in the absence of any antigens. A significant proportion of the volunteers showed suppression of one or more parameters of cell-medicated immunity tested by week 2 of infection compared to the control; however, there was no correlation between suppression of the various parameters studied. No difference was noticed in the incidence of cell-mediated immunity suppression between nose drops and subcutaneous route groups.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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