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. 1976 Feb;13(2):527–532. doi: 10.1128/iai.13.2.527-532.1976

Conditional virulence of a p-aminobenzoic acid-requiring mutant of Aspergillus fumigatus.

D K Sandhu, R S Sandhu, Z U Khan, V N Damodaran
PMCID: PMC420643  PMID: 770331

Abstract

The induced auxotrophy for p-aminobenzoic acid (PABA) resulted in a complete loss of virulence of Aspergillus fumigatus for normal as well as cortisone-treated mice. The PABA-requiring mutant of A. fumigatus survived in vivo for 4 to 7 days without causing any infection. However, it showed conditional virulence in animals receiving PABA in very small quantities. Repeated inoculations of the viable spores of the avirulent mutant strain gave favorable results in building immunity against intravenous challenge of the virulent strain. The immunogenicity of the PABA-requiring mutant was comparable with that of a wild strain of the fungus in agar gel double-diffusion tests using clinical and hyperimmune sera and in skin tests on patients with allergic bronchopulmonary aspergillosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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