Table 6.
Risk of Major and NMCR Bleeding by Timing of Preprocedure Study Drug Discontinuation
| Time of Last Study Drug Dose Relative to Procedure | Rivaroxaban (n=1131 TIs)
|
Warfarin (n=1416 TIs)
|
||||
|---|---|---|---|---|---|---|
| n | Major Bleeds | Major/ NMCR Bleeds | n | Major Bleeds | Major/ NMCR Bleeds | |
| Same day | 20 | 0 | 0 | 24 | 0 | 0 |
| 1 d prior | 23 | 1 | 1 | 19 | 0 | 1 |
| 2 d prior | 105 | 0 | 5 | 57 | 0 | 1 |
| ≥3 d prior | 983 | 13 | 24 | 1316 | 16 | 37 |
This table contains all TIs for which “surgical/invasive procedure” is the only reason for interruption and for which the procedure date is known (n=2547). NMCR indicates nonmajor clinically relevant; and TI, temporary interruption.