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. 1976 Mar;13(3):722–727. doi: 10.1128/iai.13.3.722-727.1976

Failure of endotoxin to increase nonspecific resistance to infection of lipopolysaccharide low-responder mice.

L Chedid, M Parant, C Damais, F Parant, D Juy, A Galelli
PMCID: PMC420669  PMID: 773822

Abstract

In vitro and in vivo responses to lipopolysaccharide (LPS) and various other bacterial immunostimulants were compared in c3H/He low-responder mice. The principal findings were as follows. (i) Their splenic lymphocytes were stimulated by various gram-negative mitogens such as an Escherichia coli peptidoglycan, a detoxified derivative of LPS, and even endotoxins extracted by trichloroacetic acid that are known to contain protein; spleen cells of these mice were also transformed by two other B-cell mitogens extracted from acid-fast organisms. (ii) Their macrophages were refractory to LPS and weakly responsive to a mycobacterial prepartion. (iii) LPS failed to elicit nonspecific resistance in these mice against Klebsiella pneumoniae infection. (iv) Endotoxin extracted by trichloroacetic acid and a mycobacterial preparation that could increase nonspecific resistance to infection in other strains did not protect C3H/He mice against a challenge by K. pneumoniae, although both prepartions could evoke nonspecific responses of B cells in this low-responder subline.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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