Abstract
Ferrets were sequentially infected at time intervals of 3 weeks with different influenza virus A strains. It was found that secondary infection can result in the appearance of antibodies highly cross-reacting with a virus strain closely related to the strain of first infection. Such highly cross-reacting antibodies were designated as HCR antibodies. Evidence is presented that HCR antibodies were not antineuraminidase antibodies and, in addition, were not specifically oriented to the strain with which the crossing was observed. When using time intervals of 3 weeks between infections, no increase after secondary infection of antibodies oriented to the strain of first infection was recorded. However, when time intervals of 4 to 5 months between infections were used, secondary infections resulted in an increase of antibodies oriented to the strain of first infection ("original antigenic sin") but not in the appearance of HCR antibodies. In addition, antibodies combining specifically with both infecting strains, designated as doubly specific antibodies, were found. Thus, the conclusion was reached that the original antigenic sin phenomenon and the appearance of HCR antibodies are mutually exclusive events.
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- DAVENPORT F. M., HENNESSY A. V., FRANCIS T., Jr Epidemiologic and immunologic significance of age distribution of antibody to antigenic variants of influenza virus. J Exp Med. 1953 Dec;98(6):641–656. doi: 10.1084/jem.98.6.641. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Drescher J., Desselberger U., Lubach D. Kinetics of inhibition of influenza virus hemagglutination by homologous antihemagglutinin and antineuraminidase antibodies as measured by means of the photometric antibody concentration unit method. J Virol. 1974 Dec;14(6):1361–1368. doi: 10.1128/jvi.14.6.1361-1368.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Drescher J., Masurel N. Photometric method for determination of doubly specific influenza antibody. Zentralbl Bakteriol Orig A. 1973 Dec;225(2):233–244. [PubMed] [Google Scholar]
- Drescher J., Weidauer D. Antigenic analysis of the hemagglutinating subunits of the animal influenza virus strains A-equine-2-Milford-2-63, A-equine-2-Miami-1-63 and A-Duck-England-62. J Immunol. 1969 Apr;102(4):1050–1057. [PubMed] [Google Scholar]
- FRANCIS T., Jr, DAVENPORT F. M., HENNESSY A. V. A serological recapitulation of human infection with different strains of influenza virus. Trans Assoc Am Physicians. 1953;66:231–239. [PubMed] [Google Scholar]
- FRANCIS T., Jr Influenza: the new acquayantance. Ann Intern Med. 1953 Aug;39(2):203–221. doi: 10.7326/0003-4819-39-2-203. [DOI] [PubMed] [Google Scholar]
- Fazekas de St Groth, Webster R. G. Disquisitions of Original Antigenic Sin. I. Evidence in man. J Exp Med. 1966 Sep 1;124(3):331–345. doi: 10.1084/jem.124.3.331. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fazekas de St Groth, Webster R. G. Disquisitions on Original Antigenic Sin. II. Proof in lower creatures. J Exp Med. 1966 Sep 1;124(3):347–361. doi: 10.1084/jem.124.3.347. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jennings R., Potter C. W., McLaren C. Effect of preinfection and preimmunization on the serum antibody response to subsequent immunization with heterotypic influenza vaccines. J Immunol. 1974 Dec;113(6):1834–1843. [PubMed] [Google Scholar]
- Virelizier J. L., Allison A. C., Schild G. C. Antibody responses to antigenic determinants of influenza virus hemagglutinin. II. Original antigenic sin: a bone marrow-derived lymphocyte memory phenomenon modulated by thymus-derived lymphocytes. J Exp Med. 1974 Dec 1;140(6):1571–1578. doi: 10.1084/jem.140.6.1571. [DOI] [PMC free article] [PubMed] [Google Scholar]