Abstract
Humoral immune response to ectropic leukemia viruses in AKR and C57BL/6 mice was controlled by a gene that mapped in linkage group IX. Mice of the AKR strain had an immune nonresponsive allele of this gene, whereas mice of the C57BL/6 strain had an immune responsive allele. Antibody against murine leukemia virus (MuLV) reacted primarily with p15 protein of the viral envelope. It was concluded that the failure to find antibody production in AKR mice was the result of a genetic immunological defect, rather than the result of immunological tolerance that was induced by the persistent viremia of endogenous MuLV.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aoki T., Boyse E. A., Old L. J. Wild-type Gross leukemia virus. II. Influence of immunogenetic factors on natural transmission and on the consequences of infection. J Natl Cancer Inst. 1968 Jul;41(1):97–101. [PubMed] [Google Scholar]
- Hanna M. G., Jr, Ihle J. N., Batzing B. L., Tennant T. W., Schenley C. K. Assessment of reactivities of natural antibodies to endogenous RNA tumor virus envelope antigens and virus-induced cell surface antigens. Cancer Res. 1975 Jan;35(1):164–171. [PubMed] [Google Scholar]
- Ihle J. N., Yurconic M., Jr, Hanna M. G., Jr Autogenous immunity to endogenous RNA tumor virus. Radioimmune precipitation assay of mouse serum antibody levels. J Exp Med. 1973 Jul 1;138(1):194–208. doi: 10.1084/jem.138.1.194. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kiessling R., Petranyi G., Klein G., Wigzel H. Genetic variation of in vitro cytolytic activity and in vivo rejection potential of non-immunized semi-syngeneic mice against a mouse lymphoma line. Int J Cancer. 1975 Jun 15;15(6):933–940. doi: 10.1002/ijc.2910150608. [DOI] [PubMed] [Google Scholar]
- LILLY F., BOYSE E. A., OLD L. J. GENETIC BASIS OF SUSCEPTIBILITY TO VIRAL LEUKAEMOGENESIS. Lancet. 1964 Dec 5;2(7371):1207–1209. doi: 10.1016/s0140-6736(64)91043-8. [DOI] [PubMed] [Google Scholar]
- Nowinski R. C., Kaehler S. L. Antibody to leukemia virus: widespread occurrence in inbred mice. Science. 1974 Sep 6;185(4154):869–871. doi: 10.1126/science.185.4154.869. [DOI] [PubMed] [Google Scholar]
- Nowinski R. C., Kaehler S. L., Baron J. Genetic control of natural immunity to ecotropic mouse leukemia viruses: production of endogenous immunogen. Infect Immun. 1976 Apr;13(4):1091–1097. doi: 10.1128/iai.13.4.1091-1097.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nowinski R. C., Kaehler S. L., Burgess R. R. Immune response in the mouse to endogenous leukemia viruses. Cold Spring Harb Symp Quant Biol. 1975;39(Pt 2):1123–1128. doi: 10.1101/sqb.1974.039.01.128. [DOI] [PubMed] [Google Scholar]
- Nowinski R. C., Klein P. A. Anomalous reactions of mouse alloantisera with cultured tumor cells. II. Cytotoxicity is caused by antibodies to leukemia viruses. J Immunol. 1975 Nov;115(5):1261–1268. [PubMed] [Google Scholar]
- Sato H., Boyse E. A., Aoki T., Iritani C., Old L. J. Leukemia-associated transplantation antigens related to murine leukemia virus. The X.1 system: immune response controlled by a locus linked to H-2. J Exp Med. 1973 Sep 1;138(3):593–606. doi: 10.1084/jem.138.3.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shreffler D C, Owen R D. A Serologically Detected Variant in Mouse Serum: Inheritance and Association with the Histocompatibility-2 Locus. Genetics. 1963 Jan;48(1):9–25. doi: 10.1093/genetics/48.1.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stockert E., Old L. J., Boyse E. A. The G-IX system. A cell surface allo-antigen associated with murine leukemia virus; implications regarding chromosomal integration of the viral genome. J Exp Med. 1971 Jun 1;133(6):1334–1355. doi: 10.1084/jem.133.6.1334. [DOI] [PMC free article] [PubMed] [Google Scholar]