Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1976 May;13(5):1360–1362. doi: 10.1128/iai.13.5.1360-1362.1976

Correlation between pseudomonas burn wound infection and granulocyte antibacterial activity.

D D McEuen, P Blair, V E Delbene, K Eurenius
PMCID: PMC420765  PMID: 818025

Abstract

The relationship of granulocyte bactericidal activity with three strains of pseudomonas and the virulence of these same organisms in a scald-burned rat model was investigated. Resistance to bactericidal activity was measured for each strain, using an in vitro assay and normal rat peritoneal granulocytes. Mortality was recorded for rats receiving a 30% third-degree scald burn with simultaneous pseudomonas burn wound infection. A positive correlation between mortality and resistance to bactericidal activity of granulocytes was obtained. These studies stress the importance of pseydomonas strain specificity in burn wound infection and indicate that mortality from these strains may be specifically related to their resistance to the bactericidal activity of leukocytes.

Full text

PDF
1360

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexander J. W., Fisher M. W., MacMillan B. G., Altemeier W. A. Prevention of invasive pseudomonas infection in burns with a new vaccine. Arch Surg. 1969 Aug;99(2):249–256. doi: 10.1001/archsurg.1969.01340140121018. [DOI] [PubMed] [Google Scholar]
  2. Curreri P. W., Lindberg R. B., DiVincenti F. C., Pruitt B. A., Jr Intravenous administration of carbenicillin for septicemia due to Pseudomonas aeruginosa following thermal injury. J Infect Dis. 1970 Sep;122(Suppl):S40–S47. doi: 10.1093/infdis/122.supplement_1.s40. [DOI] [PubMed] [Google Scholar]
  3. Curreri P. W., Lindberg R. B., DiVincenti F. C., Pruitt B. A., Jr Intravenous administration of carbenicillin for septicemia due to Pseudomonas aeruginosa following thermal injury. J Infect Dis. 1970 Sep;122(Suppl):S40–S47. doi: 10.1093/infdis/122.supplement_1.s40. [DOI] [PubMed] [Google Scholar]
  4. Foley F. D. The burn autopsy. Fatal complications of burns. Am J Clin Pathol. 1969 Jul;52(1):1–13. doi: 10.1093/ajcp/52.1.1. [DOI] [PubMed] [Google Scholar]
  5. Goldman J. M., Th'ng K. H. Phagocytic function of leucocytes from patients with acute myeloid and chronic granulocytic leukaemia. Br J Haematol. 1973 Sep;25(3):299–308. doi: 10.1111/j.1365-2141.1973.tb01741.x. [DOI] [PubMed] [Google Scholar]
  6. HIRSCH J. G. Phagocytin: a bactericidal substance from polymorphonuclear leucocytes. J Exp Med. 1956 May 1;103(5):589–611. doi: 10.1084/jem.103.5.589. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Holland J. F., Senn H., Banerjee T. Quantitative studies of localized leukocyte mobilization in acute leukemia. Blood. 1971 May;37(5):499–511. [PubMed] [Google Scholar]
  8. Kobayashi F. Experimental infection with Pseudomonas aeruginosa in mice. II. The fate of highly and low virulent strains in the peritoneal cavity and organs of mice. Jpn J Microbiol. 1971 Jul;15(4):301–307. [PubMed] [Google Scholar]
  9. Moncrief J. A. Burns. N Engl J Med. 1973 Mar 1;288(9):444–454. doi: 10.1056/NEJM197303012880905. [DOI] [PubMed] [Google Scholar]
  10. Moncrief J. A. The status of topical antibacterial therapy in the treatment of burns. Surgery. 1968 May;63(5):862–867. [PubMed] [Google Scholar]
  11. Pruitt B. A., Jr, DiVincenti F. C., Mason A. D., Jr, Foley F. D., Flemma R. J. The occurrence and significance of pneumonia and other pulmonary complications in burned patients: comparison of conventional and topical treatments. J Trauma. 1970 Jul;10(7):519–531. doi: 10.1097/00005373-197007000-00001. [DOI] [PubMed] [Google Scholar]
  12. SBARRA A. J., SHIRLEY W., SELVARAJ R. J., IOUCHI E., ROSENBAUM E. THE ROLE OF THE PHAGOCYTE IN HOST-PARASITE INTERACTIONS. I. THE PHAGOCYTIC CAPABILITIES OF LEUKOCYTES FROM LYMPHOPROLIFERATIVE DISORDERS. Cancer Res. 1964 Dec;24:1958–1968. [PubMed] [Google Scholar]
  13. Schwarzmann S., Boring J. R. Antiphagocytic Effect of Slime from a Mucoid Strain of Pseudomonas aeruginosa. Infect Immun. 1971 Jun;3(6):762–767. doi: 10.1128/iai.3.6.762-767.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Walker H. L., Mason A. D., Jr A standard animal burn. J Trauma. 1968 Nov;8(6):1049–1051. doi: 10.1097/00005373-196811000-00006. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES