Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1976 May;13(5):1382–1386. doi: 10.1128/iai.13.5.1382-1386.1976

Antinuclear antibodies and elevated anti-Epstein-Barr virus titers in cancer patients.

N K McCormick, K J McCormick, J J Trentin
PMCID: PMC420769  PMID: 178605

Abstract

One and one-half percent of human sera from patients seen at a clinic for treatment of cancer contained antibodies to the nuclei of chick kidney cells by indirect immunofluorescence tests. In the group of sera containing antinuclear antibodies, the geometric mean titer to Epstein-Barr virus (EBV) capsid antigen was significantly elevated. Sera obtained from normal adults or from patients with similar histological types of tumors that possessed no antinuclear antibodies contained lower levels of anti-EBV antibodies. The elevated titers to EBV were correlated with the presence or absence of antinuclear antibodies and not with a particular type or site of neoplastic disease.

Full text

PDF
1382

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson J., McCormick K. J., Stenback W. A., Trentin J. J. A plaque assay for chick-embryo-lethal-orphan (CELO) virus. Proc Soc Exp Biol Med. 1971 Feb;136(2):499–502. doi: 10.3181/00379727-136-35297. [DOI] [PubMed] [Google Scholar]
  2. Anderson J., McCormick K. J., Stenback W. A., Trentin J. J. The development of chick-embryo-lethal-orphan (CELO) virus T and V antigens in lytically infected chick kidney cells. Int J Cancer. 1971 Jan 15;7(1):59–64. doi: 10.1002/ijc.2910070107. [DOI] [PubMed] [Google Scholar]
  3. Anderson J., Yates V. J., Jasty V., Mancini L. O. The in vitro transformation by an avian adenovirus (CELO). 3. Human amnion cellcultures. J Natl Cancer Inst. 1969 Sep;43(3):575–580. [PubMed] [Google Scholar]
  4. Cannat A., Varet B. Induction of antinuclear antibodies in (CxB6) F1 mice inoculated with Graffi and Rauscher leukemogenic viruses. Proc Soc Exp Biol Med. 1972 Dec;141(3):1077–1080. doi: 10.3181/00379727-141-36936. [DOI] [PubMed] [Google Scholar]
  5. Cleymaet J. E., Nakamura R. M. Indirect immunofluorescent antinuclear antibody tests: comparison of sensitivity and specificity of different substrates. Am J Clin Pathol. 1972 Oct;58(4):388–393. doi: 10.1093/ajcp/58.5.388. [DOI] [PubMed] [Google Scholar]
  6. De Schryver A., Klein G., Henle G., Henle W., Cameron H. M., Santesson L., Clifford P. EB-virus associated serology in malignant disease: antibody levels to viral capsid antigens (VCA), membrane antigens (MA) and early antigens(EA) in patients with various neoplastic conditions. Int J Cancer. 1972 Mar 15;9(2):353–364. doi: 10.1002/ijc.2910090214. [DOI] [PubMed] [Google Scholar]
  7. EPSTEIN M. A., ACHONG B. G., BARR Y. M. VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA. Lancet. 1964 Mar 28;1(7335):702–703. doi: 10.1016/s0140-6736(64)91524-7. [DOI] [PubMed] [Google Scholar]
  8. Evans A. S., Rothfield N. F. E.B. virus and other viral antibodies in systemic lupus erythematosus. Lancet. 1973 May 19;1(7812):1127–1128. doi: 10.1016/s0140-6736(73)90444-3. [DOI] [PubMed] [Google Scholar]
  9. Evans A. S., Rothfield N. F., Niederman J. C. Raised antibody titres to E.B. virus in systemic lupus erythematosus. Lancet. 1971 Jan 23;1(7691):167–168. doi: 10.1016/s0140-6736(71)91937-4. [DOI] [PubMed] [Google Scholar]
  10. Evans D. L., Barnett J. W., Bowen J. M., Dmochowski L. Antigenic relationship between the herpesviruses of infectious bovine rhinotracheitis, Marek's disease, and Burkitt's lymphoma. J Virol. 1972 Aug;10(2):277–287. doi: 10.1128/jvi.10.2.277-287.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Gahrton G., Wahren B., Killander D., Foley G. E. Epstein-Barr and other herpes virus antibodies in children with acute leukemia. Int J Cancer. 1971 Sep 15;8(2):242–249. doi: 10.1002/ijc.2910080208. [DOI] [PubMed] [Google Scholar]
  12. Henle G., Henle W., Clifford P., Diehl V., Kafuko G. W., Kirya B. G., Klein G., Morrow R. H., Munube G. M., Pike P. Antibodies to Epstein-Barr virus in Burkitt's lymphoma and control groups. J Natl Cancer Inst. 1969 Nov;43(5):1147–1157. [PubMed] [Google Scholar]
  13. Henle G., Henle W., Diehl V. Relation of Burkitt's tumor-associated herpes-ytpe virus to infectious mononucleosis. Proc Natl Acad Sci U S A. 1968 Jan;59(1):94–101. doi: 10.1073/pnas.59.1.94. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Henle G., Henle W. Immunofluorescence in cells derived from Burkitt's lymphoma. J Bacteriol. 1966 Mar;91(3):1248–1256. doi: 10.1128/jb.91.3.1248-1256.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Henle W., Henle G. Epstein-Barr virus-related serology in Hodgkin's disease. Natl Cancer Inst Monogr. 1973 May;36:79–84. [PubMed] [Google Scholar]
  16. Henle W., Henle G., Ho H. C., Burtin P., Cachin Y., Clifford P., de Schryver A., de-Thé G., Diehl V., Klein G. Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma, other head and neck neoplasms, and control groups. J Natl Cancer Inst. 1970 Jan;44(1):225–231. [PubMed] [Google Scholar]
  17. Hinuma Y., Konn M., Yamaguchi J., Wudarski D. J., Blakeslee J. R., Jr, Grace J. T., Jr Immunofluorescence and herpes-type virus particles in the P3HR-1 Burkitt lymphoma cell line. J Virol. 1967 Oct;1(5):1045–1051. doi: 10.1128/jvi.1.5.1045-1051.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Hirshaut Y., Glade P., Vieira B. D., Ainbender E., Dvorak B., Siltzbach L. E. Sarcoidosis, another disease associated with serologic evidence for herpes-like virus infection. N Engl J Med. 1970 Sep 3;283(10):502–506. doi: 10.1056/NEJM197009032831002. [DOI] [PubMed] [Google Scholar]
  19. Johansson B., Klein G., Henle W., Henle G. Epstein-Barr virus (EBV)-associated antibody patterns in malignant lymphoma and leukemia. I. Hodgkin's disease. Int J Cancer. 1970 Nov 15;6(3):450–462. doi: 10.1002/ijc.2910060316. [DOI] [PubMed] [Google Scholar]
  20. Johansson B., Klein G., Henle W., Henle G. Epstein-Barr virus (EBV)-associated antibody patterns in malignant lymphoma and leukemia. II. Chronic lymphocytic leukemia and lymphocytic lymphoma. Int J Cancer. 1971 Nov 15;8(3):475–486. doi: 10.1002/ijc.2910080316. [DOI] [PubMed] [Google Scholar]
  21. Kaplan M. E., Tan E. M. Antinuclear antibodies in infectious mononucleosis. Lancet. 1968 Mar 16;1(7542):561–563. doi: 10.1016/s0140-6736(68)92831-6. [DOI] [PubMed] [Google Scholar]
  22. Kawamura A., Jr, Hamajima K., Murata M., Gotoh A., Takada M. Studies on nasopharyngeal carcinoma and Burkitt lymphoma by immunofluorescence. Ann N Y Acad Sci. 1971 Jun 21;177:250–267. doi: 10.1111/j.1749-6632.1971.tb35055.x. [DOI] [PubMed] [Google Scholar]
  23. Levine P. H., Ablashi D. V., Berard C. W., Carbone P. P., Waggoner D. E., Malan L. Elevated antibody titers to Epstein-Barr virus in Hodgkin's disease. Cancer. 1971 Feb;27(2):416–421. doi: 10.1002/1097-0142(197102)27:2<416::aid-cncr2820270227>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
  24. McCormick N. K., McCormick K. J., Trentin J. J. Microtechnique for indirect immunofluorescence. Appl Microbiol. 1973 Dec;26(6):1015–1015. doi: 10.1128/am.26.6.1015-1015.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Niederman J. C., McCollum R. W., Henle G., Henle W. Infectious mononucleosis. Clinical manifestations in relation to EB virus antibodies. JAMA. 1968 Jan 15;203(3):205–209. doi: 10.1001/jama.203.3.205. [DOI] [PubMed] [Google Scholar]
  26. Ono K., Tanabe S., Naito M., Doi T., Kato S. Antigen common to a herpes type virus from chickens with Marek's disease and EB virus from Burkitt's lymphoma cells. Biken J. 1970 Sep;13(3):213–217. [PubMed] [Google Scholar]
  27. Papageorgiou P. S., Sorokin C., Kouzoutzakoglou K., Glade P. R. Herpes-like Epstein-Barr virus in leprosy. Nature. 1971 May 7;231(5297):47–49. doi: 10.1038/231047a0. [DOI] [PubMed] [Google Scholar]
  28. TODARO G. J., GREEN H. Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J Cell Biol. 1963 May;17:299–313. doi: 10.1083/jcb.17.2.299. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Wahren B., Carlens E., Espmark A., Lundbeck H., Löfgren S., Madar E., Henle G., Henle W. Antibodies to various herpesviruses in sera from patients with sarcoidosis. J Natl Cancer Inst. 1971 Oct;47(4):747–755. [PubMed] [Google Scholar]
  30. de Schryver A., Friberg S., Jr, Klein G., Henle W., Henle G., De-Thé G., Clifford P., Ho H. C. Epstein-Barr virus-associated antibody patterns in carcinoma of the post-nasal space. Clin Exp Immunol. 1969 Nov;5(5):443–459. [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES