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Infection and Immunity logoLink to Infection and Immunity
. 1976 Jun;13(6):1585–1590. doi: 10.1128/iai.13.6.1585-1590.1976

Immunogenicity of a purified and carrier-complexed streptococcal lipoteichoic acid.

B A Fiedel, R W Jackson
PMCID: PMC420804  PMID: 786876

Abstract

Solublie teichoic acid could not stimulate the formation of antibodies either as an aqueous solution or in an emulsion with Freund incomplete adjuvant. However, when given as precipitates with methylated bovine serum albumin, it stimulated strong anti-teichoic acid responses. High levels of anti-teichoic acid antibodies usually resulted in allergic symptoms upon secondary challenge either with immunogenic teichoic acid-methylated bovine albumin complexes or with non-immunogenic soluble teichoic acid. These symptoms suggested anaphylatic shock, but probably also included the formation of complement-consuming immune complexes.

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Selected References

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  1. AMES B. N., DUBIN D. T. The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. J Biol Chem. 1960 Mar;235:769–775. [PubMed] [Google Scholar]
  2. ARMSTRONG J. J., BADDILEY J., BUCHANAN J. G., CARSS B. Nucleotides and the bacterial cell wall. Nature. 1958 Jun 21;181(4625):1692–1693. doi: 10.1038/1811692a0. [DOI] [PubMed] [Google Scholar]
  3. Archibald A. R., Baddiley J., Blumsom N. L. The teichoic acids. Adv Enzymol Relat Areas Mol Biol. 1968;30:223–253. doi: 10.1002/9780470122754.ch5. [DOI] [PubMed] [Google Scholar]
  4. Boylan R. J., Mendelson N. H., Brooks D., Young F. E. Regulation of the bacterial cell wall: analysis of a mutant of Bacillus subtilis defective in biosynthesis of teichoic acid. J Bacteriol. 1972 Apr;110(1):281–290. doi: 10.1128/jb.110.1.281-290.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Burger M. M. Teichoic acids: antigenic determinants, chain separation, and their location in the cell wall. Proc Natl Acad Sci U S A. 1966 Sep;56(3):910–917. doi: 10.1073/pnas.56.3.910. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hewett M. J., Knox K. W., Wicken A. J. Studies on the group F antigen of lactobacilli: detection of antibodies by haemagglutination. J Gen Microbiol. 1970 Mar;60(3):315–322. doi: 10.1099/00221287-60-3-315. [DOI] [PubMed] [Google Scholar]
  7. Knox K. W., Hewett M. J., Wicken A. J. Studies on the group F antigen of lactobacilli: antigenicity and serological specificity of teichoic acid preparations. J Gen Microbiol. 1970 Mar;60(3):303–313. doi: 10.1099/00221287-60-3-303. [DOI] [PubMed] [Google Scholar]
  8. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  9. MCCARTY M., MORSE S. I. CELL WALL ANTIGENS OF GRAM-POSITIVE BACTERIA. Adv Immunol. 1964;27:249–286. doi: 10.1016/s0065-2776(08)60709-9. [DOI] [PubMed] [Google Scholar]
  10. McCARTY M. The occurrence of polyglycerophosphate as an antigenic component of various gram-positive bacterial species. J Exp Med. 1959 Apr 1;109(4):361–378. doi: 10.1084/jem.109.4.361. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Miller G. A., Jackson R. W. The effect of a streptococcus pyogenes teichoic acid on the immune response of mice. J Immunol. 1973 Jan;110(1):148–156. [PubMed] [Google Scholar]
  12. Moskowitz M. Separation and properties of a red cell sensitizing substance from streptococci. J Bacteriol. 1966 Jun;91(6):2200–2204. doi: 10.1128/jb.91.6.2200-2204.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Ne'eman N., Ginsburg I. Red cell-sensitizing antigen of group A streptococci. II. Immunological and immunopathological properties. Isr J Med Sci. 1972 Nov;8(11):1807–1816. [PubMed] [Google Scholar]
  14. Pavlovskis O., Slade H. D. Adsorption of 3H-fatty acid esters of streptococcal groups A and E cell wall polysaccharide antigens by red blood cells and their effect on hemagglutination. J Bacteriol. 1969 Nov;100(2):641–646. doi: 10.1128/jb.100.2.641-646.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. SANDERSON A. R., STROMINGER J. L., NATHENSON S. G. Chemical structure of teichoic acid from Staphylococcus aureus, strain Copenhagen. J Biol Chem. 1962 Dec;237:3603–3613. [PubMed] [Google Scholar]
  16. SHARPE M. E., DAVISON A. L., BADDILEY J. TEICHOIC ACIDS AND GROUP ANTIGENS IN LACTOBACILLI. J Gen Microbiol. 1964 Feb;34:333–340. doi: 10.1099/00221287-34-2-333. [DOI] [PubMed] [Google Scholar]
  17. Toon P., Brown P. E., Baddiley J. The lipid-teichoic acid complex in the cytoplasmic membrane of Streptococcus faecalis N.C.I.B. 8191. Biochem J. 1972 Apr;127(2):399–409. doi: 10.1042/bj1270399. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. WICKEN A. J., ELLIOTT S. D., BADDILEY J. The identity of streptococcal group D antigen with teichoic acid. J Gen Microbiol. 1963 May;31:231–239. doi: 10.1099/00221287-31-2-231. [DOI] [PubMed] [Google Scholar]
  19. Wicken A. J., Gibbens J. W., Knox K. W. Comparative studies on the isolation of membrane lipoteichoic acid from Lactobacillus fermenti. J Bacteriol. 1973 Jan;113(1):365–372. doi: 10.1128/jb.113.1.365-372.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Wicken A. J., Knox K. W. Studies on the group F antigen of lactobacilli: isolation of a teichoic acid-lipid complex from Lactobacillus fermenti NCTC 6991. J Gen Microbiol. 1970 Mar;60(3):293–301. doi: 10.1099/00221287-60-3-293. [DOI] [PubMed] [Google Scholar]
  21. Young F. E. Requirement of glucosylated teichoic acid for adsorption of phage in Bacillus subtilis 168. Proc Natl Acad Sci U S A. 1967 Dec;58(6):2377–2384. doi: 10.1073/pnas.58.6.2377. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Young F. E., Smith C., Reilly B. E. Chromosomal location of genes regulating resistance to bacteriophage in Bacillus subtilis. J Bacteriol. 1969 Jun;98(3):1087–1097. doi: 10.1128/jb.98.3.1087-1097.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]

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