Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1976 Jun;13(6):1619–1625. doi: 10.1128/iai.13.6.1619-1625.1976

Inactivation of hemolytic complement in human serum by an acylated polysaccharide from a gram-positive rod: possible significance in pigeon-breeder's disease.

J H Huis in 't Veld, L Berrens
PMCID: PMC420810  PMID: 971942

Abstract

In an attempt to identify the major complement-consuming heteropolysaccharides in pigeon excreta, a number of teichoic acids and lipoteichoic acids from gram-positive bacteria were examined as possible substitutes. Teichoic acids from the cell wall and membrane of Lactobacillus buchnerii were found suitable. Samples of freshly voided pigeon droppings were cultured under anaerobic conditions and the bacteria were identified, subcultured, and extracted with phenol-water. Cell wall and membrane antigens from isolated Lactobacillus species could replace pigeon excreta antigens in diagnostic complement consumption tests. Purification and chemical characterization indicated the major antigen from Lactobacillus in this respect to be an acylated heteropolysaccharide.

Full text

PDF
1619

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berrens L., Guikers C. L. An immunochemical study of pigeon-breeder's disease. IV. A highly selective in vitro test for pigeon fancier's lung based on complement (C3) inactivation. Int Arch Allergy Appl Immunol. 1972;43(3):347–359. [PubMed] [Google Scholar]
  2. Berrens L., Guikers C. L., van Dijk A. The antigens in pigeon-breeder's disease and their interaction with human complement. Ann N Y Acad Sci. 1974;221:153–162. doi: 10.1111/j.1749-6632.1974.tb28213.x. [DOI] [PubMed] [Google Scholar]
  3. Berrens L., Maesen F. P. An immunochemical study of pigeon-breeder's disease. I. The aselective antigens. Int Arch Allergy Appl Immunol. 1972;43(2):289–304. doi: 10.1159/000230843. [DOI] [PubMed] [Google Scholar]
  4. Berrens L., Maesen F. P. An immunochemical study of pigeon-breeder's disease. Int Arch Allergy Appl Immunol. 1972;43(3):327–336. doi: 10.1159/000230848. [DOI] [PubMed] [Google Scholar]
  5. Bolton R. W., Chorpenning F. W. Naturally occurring cellular and humoral immunity to teichoic acid in rats. Immunology. 1974 Oct;27(4):517–524. [PMC free article] [PubMed] [Google Scholar]
  6. Brundish D. E., Baddiley J. Pneumococcal C-substance, a ribitol teichoic acid containing choline phosphate. Biochem J. 1968 Dec;110(3):573–582. doi: 10.1042/bj1100573. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Decker G. P., Chorpenning F. W., Frederick G. T. Naturally-occurring antibodies to bacillary teichoic acids. J Immunol. 1972 Jan;108(1):214–222. [PubMed] [Google Scholar]
  8. Faux J. A., Holford-Strevens V., Wells I. D., Pepys J. 'False positive' precipitation reactions to extracts of organic dusts due to a teichoic acid from S. aureus. Techniques. Clin Exp Immunol. 1970 Dec;7(6):897–902. [PMC free article] [PubMed] [Google Scholar]
  9. Frederick T. G., Chorpenning F. W. Characterization of antibodies specific for polyglycerophosphate. J Immunol. 1974 Aug;113(2):489–495. [PubMed] [Google Scholar]
  10. HANES C. S., ISHERWOOD F. A. Separation of the phosphoric esters on the filter paper chromatogram. Nature. 1949 Dec 31;164(4183):1107-12, illust. doi: 10.1038/1641107a0. [DOI] [PubMed] [Google Scholar]
  11. Pless D. D., Schmit A. S., Lennarz W. J. The characterization of mannan of Micrococcus lysodeikticus as an acidic lipopolysaccharide. J Biol Chem. 1975 Feb 25;250(4):1319–1327. [PubMed] [Google Scholar]
  12. Powell D. A., Duckworth M., Baddiley J. An acylated mannan in the membrane of Micrococcus lysodeikticus. FEBS Lett. 1974 May 1;41(2):259–263. doi: 10.1016/0014-5793(74)81225-1. [DOI] [PubMed] [Google Scholar]
  13. RADIN N. S., LAVIN F. B., BROWN J. R. Determination of cerebrosides. J Biol Chem. 1955 Dec;217(2):789–796. [PubMed] [Google Scholar]
  14. Sandberg A. L., Snyderman R., Frank M. M., Osler A. G. Production of chemotactic activity by guinea pig immunoglobulins following activation of the C3 complement shunt pathway. J Immunol. 1972 May;108(5):1227–1231. [PubMed] [Google Scholar]
  15. TREVELYAN W. E., PROCTER D. P., HARRISON J. S. Detection of sugars on paper chromatograms. Nature. 1950 Sep 9;166(4219):444–445. doi: 10.1038/166444b0. [DOI] [PubMed] [Google Scholar]
  16. Van Driel D., Wicken A. J., Dickson M. R., Knox K. W. Cellular location of the lipoteichoic acids of Lactobacillus fermenti NCTC 6991 and Lactobacillus casei NCTC 6375. J Ultrastruct Res. 1973 Jun;43(5):483–497. doi: 10.1016/s0022-5320(73)90025-7. [DOI] [PubMed] [Google Scholar]
  17. Volanakis J. E., Kaplan M. H. Interaction of C-reactive protein complexes with the complement system. II. Consumption of guinea pig complement by CRP complexes: requirement for human C1q. J Immunol. 1974 Jul;113(1):9–17. [PubMed] [Google Scholar]
  18. Wiel-Korstanje JA van D., Winkler K. C. Medium for differential count of the anaerobic flora in human feces. Appl Microbiol. 1970 Jul;20(1):168–169. doi: 10.1128/am.20.1.168-169.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES