Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1976 Jul;14(1):212–216. doi: 10.1128/iai.14.1.212-216.1976

Effect of passive antibody on parainfluenza virus type 3 pneumonia in hamsters.

W P Glezen, G W Fernald
PMCID: PMC420865  PMID: 181324

Abstract

Both parainfluenza virus type 3 and respiratory syncytial virus may produce life-threatening pneumonia or bronchiolitis in infants less than 6 months old. Almost all infants in this age group possess passively acquired maternal antibodies to both viruses. It has been suggested that maternal antibodies may actually participate in the pathogenesis of these diseases in early infancy. This investigation examined the effect of moderate levels of passive antibody on the development of pneumonia in hamsters infected intranasally with parainfluenza virus type 3. The pneumonitis produced in this model was not enhanced by the presence of moderate levels of serum antibody to this virus. Furthermore, reinfection after an initial "sensitizing" infection under the cover of passive antibody did not result in a more severe pneumonitis. These studies do not support either of the two hypotheses that have been advanced to explain the pathogenesis of infections with respiratory syncytial virus in early infancy.

Full text

PDF
212

Images in this article

213Image
on p.213

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BUTHALA D. A., SORET M. G. PARAINFLUENZA TYPE 3 VIRUS INFECTION IN HAMSTERS: VIROLOGIC, SEROLOGIC, AND PATHOLOGIC STUDIES. J Infect Dis. 1964 Jun;114:226–234. doi: 10.1093/infdis/114.3.226. [DOI] [PubMed] [Google Scholar]
  2. CHANOCK R. M., PARROTT R. H. ACUTE RESPIRATORY DISEASE IN INFANCY AND CHILDHOOD: PRESENT UNDERSTANDING AND PROSPECTS FOR PREVENTION. Pediatrics. 1965 Jul;36:21–39. [PubMed] [Google Scholar]
  3. CRAIGHEAD J. E., COOK M. K., CHANOCK R. M. Infection of hamsters with para influenza 3 virus. Proc Soc Exp Biol Med. 1960 Jun;104:301–304. doi: 10.3181/00379727-104-25816. [DOI] [PubMed] [Google Scholar]
  4. Chanock R. M., Kapikian A. Z., Mills J., Kim H. W., Parrott R. H. Influence of immunological factors in respiratory syncytial virus disease. Arch Environ Health. 1970 Sep;21(3):347–355. doi: 10.1080/00039896.1970.10667249. [DOI] [PubMed] [Google Scholar]
  5. DE ST. GROTH S. F., GRAHAM D. M. Studies in experimental immunology of influenza. X. Passive immunity and its enhancement. Aust J Exp Biol Med Sci. 1954 Jun;32(3):369–386. doi: 10.1038/icb.1954.40. [DOI] [PubMed] [Google Scholar]
  6. GARDNER P. S., ELDERKIN F. M., WALL A. H. SEROLOGICAL STUDY OF RESPIRATORY SYNCYTIAL VIRUS INFECTIONS IN INFANCY AND CHILDHOOD. Br Med J. 1964 Dec 19;2(5424):1570–1573. doi: 10.1136/bmj.2.5424.1570. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gardner P. S., McQuillin J., Court S. D. Speculation on pathogenesis in death from respiratory syncytial virus infection. Br Med J. 1970 Feb 7;1(5692):327–330. doi: 10.1136/bmj.1.5692.327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gardner P. S., McQuillin J., McGuckin R., Ditchburn R. K. Observations on clinical and immunofluorescent diagnosis of parainfluenza virus infections. Br Med J. 1971 Apr 3;2(5752):7–12. doi: 10.1136/bmj.2.5752.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Glezen P., Denny F. W. Epidemiology of acute lower respiratory disease in children. N Engl J Med. 1973 Mar 8;288(10):498–505. doi: 10.1056/NEJM197303082881005. [DOI] [PubMed] [Google Scholar]
  10. Glezen W. P., Loda F. A., Clyde W. A., Jr, Senior R. J., Sheaffer C. I., Conley W. G., Denny F. W. Epidemiologic patterns of acute lower respiratory disease of children in a pediatric group practice. J Pediatr. 1971 Mar;78(3):397–406. doi: 10.1016/s0022-3476(71)80218-4. [DOI] [PubMed] [Google Scholar]
  11. LEPOW M. L., WARREN R. J., GRAY N., INGRAM V. G., ROBBINS F. C. Effect of Sabin Type 1 poliomyelitis vaccine administered by mouth to newborn infants. N Engl J Med. 1961 May 25;264:1071–1078. doi: 10.1056/NEJM196105252642102. [DOI] [PubMed] [Google Scholar]
  12. Liu C., Sharp E., Collins J. Studies on the pathogenesis of parainfluenza type 3 virus infection in hamsters. Arch Gesamte Virusforsch. 1968;24(3):203–219. doi: 10.1007/BF01241293. [DOI] [PubMed] [Google Scholar]
  13. Mufson M. A., Krause H. E., Mocega H. E., Dawson F. W. Viruses, Mycoplasma pneumoniae and bacteria associated with lower respiratory tract disease among infants. Am J Epidemiol. 1970 Feb;91(2):192–202. doi: 10.1093/oxfordjournals.aje.a121128. [DOI] [PubMed] [Google Scholar]
  14. Ross C. A., Pinkerton I. W., Assaad F. A. Pathogenesis of respiratory syncytial virus diseases in infancy. Arch Dis Child. 1971 Oct;46(249):702–704. doi: 10.1136/adc.46.249.702. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES