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. 1976 Aug;14(2):422–428. doi: 10.1128/iai.14.2.422-428.1976

Lymphocyte populations in acute viral gastroenteritis.

R Dolin, R C Reichman, A S Fauci
PMCID: PMC420901  PMID: 1085751

Abstract

Viral gastroenteritis was induced in 16 of 24 normal volunteers after oral administration of either the Norwalk or Hawaii agents. Clinical illness lasted for 24 to 48 h and resolved spontaneously. During acute illness, a transient lymphopenia was noted which involved all lymphocyte subpopulations (thymus-and bone marrow-derived, and null cells). No circulating lymphocytotoxins were detected, and the lymphocytes remaining in the circulation responded normally to mitogenic stimuli. The acute lymphopenia occurred at the time that mononuclear cell infiltration of the jejunal mucosa has been noted. These findings are consistent with the occurrence of a redistribution of circulating lymphocytes during acute illness, with accumulation of lymphocytes at the site of infection in the gut.

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Selected References

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  1. Agus S. G., Dolin R., Wyatt R. G., Tousimis A. J., Northrup R. S. Acute infectious nonbacterial gastroenteritis: intestinal histopathology. Histologic and enzymatic alterations during illness produced by the Norwalk agent in man. Ann Intern Med. 1973 Jul;79(1):18–25. doi: 10.7326/0003-4819-79-1-18. [DOI] [PubMed] [Google Scholar]
  2. Aiuti F., Ciarla M. V., D'Asero C., D'Amelio R., Garofalo J. A. Surface markers on lymphocytes of patients with infectious diseases. Infect Immun. 1973 Jul;8(1):110–117. doi: 10.1128/iai.8.1.110-117.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Allison A. C. Cell-mediated immune responses to virus infections and virus-induced tumours. Br Med Bull. 1967 Jan;23(1):60–65. doi: 10.1093/oxfordjournals.bmb.a070518. [DOI] [PubMed] [Google Scholar]
  4. Bianco C., Patrick R., Nussenzweig V. A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization. J Exp Med. 1970 Oct 1;132(4):702–720. doi: 10.1084/jem.132.4.702. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DINGLE J. H., BADGER G. F., FELLER A. E., HODGES R. G., JORDAN W. S., Jr, RAMMELKAMP C. H., Jr A study of illness in a group of Cleveland families. I. Plan of study and certain general observations. Am J Hyg. 1953 Jul;58(1):16–30. doi: 10.1093/oxfordjournals.aje.a119587. [DOI] [PubMed] [Google Scholar]
  6. Dolin R., Blacklow N. R., DuPont H., Buscho R. F., Wyatt R. G., Kasel J. A., Hornick R., Chanock R. M. Biological properties of Norwalk agent of acute infectious nonbacterial gastroenteritis. Proc Soc Exp Biol Med. 1972 Jun;140(2):578–583. doi: 10.3181/00379727-140-36508. [DOI] [PubMed] [Google Scholar]
  7. Dolin R., Levy A. G., Wyatt R. G., Thornhill T. S., Gardner J. D. Viral gastroenteritis induced by the Hawaii agent. Jejunal histopathology and serologic response. Am J Med. 1975 Dec;59(6):761–768. doi: 10.1016/0002-9343(75)90461-1. [DOI] [PubMed] [Google Scholar]
  8. Douglas R. G., Jr, Alford R. H., Cate T. R., Couch R. B. The leukocyte response during viral respiratory illness in man. Ann Intern Med. 1966 Mar;64(3):521–530. doi: 10.7326/0003-4819-64-3-521. [DOI] [PubMed] [Google Scholar]
  9. Fauci A. S. Mechanisms of corticosteroid action on lymphocyte subpopulations. I. Redistribution of circulating T and b lymphocytes to the bone marrow. Immunology. 1975 Apr;28(4):669–680. [PMC free article] [PubMed] [Google Scholar]
  10. Fireman P., Friday G., Kumate J. Effect of measles vaccine on immunologic responsiveness. Pediatrics. 1969 Feb;43(2):264–272. [PubMed] [Google Scholar]
  11. Flad G. D., Huber C., Bremer K., Menne H. D., Huber H. Impaired recirculation of B lymphocytes in chronic lymphocytic leukemia. Eur J Immunol. 1973 Nov;3(11):688–693. doi: 10.1002/eji.1830031107. [DOI] [PubMed] [Google Scholar]
  12. Gillette S., Bellanti J. A. Kinetics of lymphoid cells in tumor-bearing mice. Cell Immunol. 1973 Aug;8(2):311–320. doi: 10.1016/0008-8749(73)90120-2. [DOI] [PubMed] [Google Scholar]
  13. Glasgow L. A. Cellular immunity in host resistance to viral infections. Arch Intern Med. 1970 Jul;126(1):125–134. [PubMed] [Google Scholar]
  14. HILLENBRAND F. K. The blood picture in rubella; its place in diagnosis. Lancet. 1956 Jul 14;271(6933):66–68. doi: 10.1016/s0140-6736(56)90427-5. [DOI] [PubMed] [Google Scholar]
  15. Hartzman R. J., Bach M. L., Bach F. H., Thurman G. B., Sell K. W. Precipitation of radioactively labeled samples: a semi-automatic multiple-sample processor. Cell Immunol. 1972 Jun;4(2):182–186. doi: 10.1016/0008-8749(72)90018-4. [DOI] [PubMed] [Google Scholar]
  16. Huang S. W., Lattos D. B., Nelson D. B., Reeb K., Hong R. Antibody-associated lymphotoxin in acute infection. J Clin Invest. 1973 May;52(5):1033–1040. doi: 10.1172/JCI107268. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. JOHNSON E. S., NAPOLI V. M., WHITE W. C. Colorado tick fever as a hematologic problem. Am J Clin Pathol. 1960 Aug;34:118–124. doi: 10.1093/ajcp/34.2.118. [DOI] [PubMed] [Google Scholar]
  18. Jondal M., Holm G., Wigzell H. Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. J Exp Med. 1972 Aug 1;136(2):207–215. doi: 10.1084/jem.136.2.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Jondal M., Wigzell H., Aiuti F. Human lymphocyte subpopulations: classification according to surface markers and-or functional characteristics. Transplant Rev. 1973;16:163–195. doi: 10.1111/j.1600-065x.1973.tb00120.x. [DOI] [PubMed] [Google Scholar]
  20. KNIGHT V. THE USE OF VOLUNTEERS IN MEDICAL VIROLOGY. Prog Med Virol. 1964;6:1–26. [PubMed] [Google Scholar]
  21. Kantzler G. B., Lauteria S. F., Cusumano C. L., Lee J. D., Ganguly R., Waldman R. H. Immunosuppression during influenza virus infection. Infect Immun. 1974 Nov;10(5):996–1002. doi: 10.1128/iai.10.5.996-1002.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Kapikian A. Z., Gerin J. L., Wyatt R. G., Thornhill T. S., Chanock R. M. Density in cesium chloride of the 27 nm "8FIIa" particle associated with acute infectious nonbacterial gastroenteritis: determination by ultra-centrifugation and immune electron microscopy. Proc Soc Exp Biol Med. 1973 Mar;142(3):874–877. doi: 10.3181/00379727-142-37135. [DOI] [PubMed] [Google Scholar]
  23. Kapikian A. Z., Wyatt R. G., Dolin R., Thornhill T. S., Kalica A. R., Chanock R. M. Visualization by immune electron microscopy of a 27-nm particle associated with acute infectious nonbacterial gastroenteritis. J Virol. 1972 Nov;10(5):1075–1081. doi: 10.1128/jvi.10.5.1075-1081.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Levine M. A., Claman H. N. Bone marrow and spleen: dissociation of immunologic properties by cortisone. Science. 1970 Mar 13;167(3924):1515–1517. doi: 10.1126/science.167.3924.1515. [DOI] [PubMed] [Google Scholar]
  25. Mangi R. J., Dwyer J. M., Niederman J. C., Kantor F. S. Letter: Decreased circulating T cells during viral pharyngitis. Ann Intern Med. 1974 Oct;81(4):557–558. doi: 10.7326/0003-4819-81-4-557_2. [DOI] [PubMed] [Google Scholar]
  26. Mangi R. J., Niederman J. C., Kelleher J. E., Jr, Dwyer J. M., Evans A. S., Kantor F. S. Depression of cell-mediated immunity during acute infectious mononucleosis. N Engl J Med. 1974 Nov 28;291(22):1149–1153. doi: 10.1056/NEJM197411282912202. [DOI] [PubMed] [Google Scholar]
  27. Mella B., Lang D. J. Leukocyte mitosis: suppression in vitro associated with acute infectious hepatitis. Science. 1967 Jan 6;155(3758):80–81. doi: 10.1126/science.155.3758.80. [DOI] [PubMed] [Google Scholar]
  28. Munyer T. P., Mangi R. J., Dolan T., Kantor F. S. Depressed lymphocyte function after measles-mumps-rubella vaccination. J Infect Dis. 1975 Jul;132(1):75–78. doi: 10.1093/infdis/132.1.75. [DOI] [PubMed] [Google Scholar]
  29. Niklasson P. M., Williams R. C., Jr Studies of peripheral blood T-and B-lymphocytes in acute infections. Infect Immun. 1974 Jan;9(1):1–7. doi: 10.1128/iai.9.1.1-7.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Olson G. B., South M. A., Good R. A. Phytohaemagglutinin unresponsiveness of lymphocytes from babies with congenital rubella. Nature. 1967 May 13;214(5089):695–696. doi: 10.1038/214695a0. [DOI] [PubMed] [Google Scholar]
  31. Schreiber D. S., Blacklow N. R., Trier J. S. The mucosal lesion of the proximal small intestine in acute infectious nonbacterial gastroenteritis. N Engl J Med. 1973 Jun 21;288(25):1318–1323. doi: 10.1056/NEJM197306212882503. [DOI] [PubMed] [Google Scholar]
  32. Schreiber D. S., Blacklow N. R., Trier J. S. The small intestinal lesion induced by Hawaii agent acute infectious nonbacterial gastroenteritis. J Infect Dis. 1974 Jun;129(6):705–708. doi: 10.1093/infdis/129.6.705. [DOI] [PubMed] [Google Scholar]
  33. TERASAKI P. I., MCCLELLAND J. D. MICRODROPLET ASSAY OF HUMAN SERUM CYTOTOXINS. Nature. 1964 Dec 5;204:998–1000. doi: 10.1038/204998b0. [DOI] [PubMed] [Google Scholar]
  34. Wheelock E. F., Toy S. T. Participation of lymphocytes in viral infections. Adv Immunol. 1973;16:123–184. doi: 10.1016/s0065-2776(08)60297-7. [DOI] [PubMed] [Google Scholar]
  35. Woodruff J. J., Woodruff J. F. Virus-induced alterations of lymphoid tissue. IV. The effect of Newcastle disease virus on the fate of transfused thoracic duct lymphocytes. Cell Immunol. 1974 Jan;10(1):78–85. doi: 10.1016/0008-8749(74)90153-1. [DOI] [PubMed] [Google Scholar]
  36. Wyatt R. G., Dolin R., Blacklow N. R., DuPont H. L., Buscho R. F., Thornhill T. S., Kapikian A. Z., Chanock R. M. Comparison of three agents of acute infectious nonbacterial gastroenteritis by cross-challenge in volunteers. J Infect Dis. 1974 Jun;129(6):709–714. doi: 10.1093/infdis/129.6.709. [DOI] [PubMed] [Google Scholar]
  37. Wybran J., Fudenberg H. H. Thymus-derived rosette-forming cells in various human disease states: cancer, lymphoma, bacterial and viral infections, and other diseases. J Clin Invest. 1973 May;52(5):1026–1032. doi: 10.1172/JCI107267. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Zweiman B., Pappagianis D., Maibach H., Hildreth E. A. Effect of measles immunization on tuberculin hypersensitivity and in vitro lymphocyte reactivity. Int Arch Allergy Appl Immunol. 1971;40(6):834–841. doi: 10.1159/000230466. [DOI] [PubMed] [Google Scholar]
  39. van der VIES Individual determination of cortisol and corticosterone in a single small sample of peripheral blood. Acta Endocrinol (Copenh) 1961 Nov;38:399–406. doi: 10.1530/acta.0.0380399. [DOI] [PubMed] [Google Scholar]

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