Abstract
In Tunisia (North Africa), trachoma remains a common eye disease. Most cases are caused by immunotype A of Chlamydia trachomatis. In a small proportion of cases (less than 10%), type-specific antibodies to both immunotype A and immunotype B exist in the serum of patients. These types do not crossreact, and occasionally sequential acquisition of antibodies has been demonstrated. Thus, individuals in one endemic area of trachoma may be infected with two immunotypes of C. trachomatis. The epidemiological and immunological implications of this new finding are briefly discussed.
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Selected References
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- Barenfanger J., MacDonald A. B. The role of immunoglobulin in the neutralization of trachoma infectivity. J Immunol. 1974 Nov;113(5):1607–1617. [PubMed] [Google Scholar]
- Barenfanger J. Studies on the role of the famiy unit in the transmission of trachoma. Am J Trop Med Hyg. 1975 May;24(3):509–515. doi: 10.4269/ajtmh.1975.24.509. [DOI] [PubMed] [Google Scholar]
- Bell S. D., McComb D. E., Nichols R. L., Roca-Garcia M. Studies on trachoma. VII. Isolation of a mixture of type 1 and type 2. Trachoma strains from a child in Saudi Arabia. Am J Trop Med Hyg. 1970 Sep;19(5):842–845. [PubMed] [Google Scholar]
- Briones O. C., Hanna L., Jawetz E., Dawson C. R., Ostler H. B. Type-specific antibodies in human Chlamydia trachomatis infections of the eye. J Immunol. 1974 Oct;113(4):1262–1270. [PubMed] [Google Scholar]
- Dawson C. R., Hoshiwara I., Daghfous T., Messadi M., Vastine D. W., Schachter J. Topical tetracycline and rifampicin therapy of endemic trachoma in Tunisia. Am J Ophthalmol. 1975 May;79(5):803–811. doi: 10.1016/0002-9394(75)90740-0. [DOI] [PubMed] [Google Scholar]
- Grayston J. T., Wang S. New knowledge of chlamydiae and the diseases they cause. J Infect Dis. 1975 Jul;132(1):87–105. doi: 10.1093/infdis/132.1.87. [DOI] [PubMed] [Google Scholar]
- Hanna L., Jawetz E., Briones O., Ostler H. B., Keshishyan H., Dawson C. R. Antibodies to TRIC agents in matched human tears and sera. J Immunol. 1973 Jun;110(6):1464–1469. [PubMed] [Google Scholar]
- Hanna L., Jawetz E., Nabli B., Hoshiwara I., Ostler B., Dawson C. Titration and typing of serum antibodies in TRIC infections by immunofluorescence. J Immunol. 1972 Jan;108(1):102–107. [PubMed] [Google Scholar]
- Wang S. P., Grayston J. T. Immunologic relationship between genital TRIC, lymphogranuloma venereum, and related organisms in a new microtiter indirect immunofluorescence test. Am J Ophthalmol. 1970 Sep;70(3):367–374. doi: 10.1016/0002-9394(70)90096-6. [DOI] [PubMed] [Google Scholar]