Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1976 Aug;14(2):483–489. doi: 10.1128/iai.14.2.483-489.1976

Rat polyvinyl sponge model for the study of infections: initial investigations.

H D Isenberg, S L Wiener, G A Isenberg, J Sampson-Scherer, M Urivetzky, J I Berkman
PMCID: PMC420910  PMID: 823113

Abstract

Polyvinyl sponges were implanted subcutaneously on both sides of young female rats. One sponge was infected with 10(8) of either Escherichia coli K-12 F-, Staphylococcus aureus ATCC 25923, or Pseudomonas aeruginosa CDC 7725. P. aeruginosa remained at the inoculum level and S. aureus declined by 1 log, whereas E. coli was reduced 1,000-fold. Only P. aeruginosa was recovered from the blood in 36% of the animals in 24 h and in 20% of the rats in 48 h. The nutrient potential of rat inflammatory fluid was compared to nutrient broth by growth of each bacterium in untreated and heat-inactivated sponge fluids and Trypticase soy broth.

Full text

PDF
483

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bartell P. F., Orr T. E., Garcia M. The lethal events in experimental Pseudomonas aeruginosa infection of mice. J Infect Dis. 1968 Apr;118(2):165–172. doi: 10.1093/infdis/118.2.165. [DOI] [PubMed] [Google Scholar]
  2. Cherry W. B., Moss C. W. The role of gas chromatography in the clinical microbiology laboratory. J Infect Dis. 1969 Jun;119(6):658–662. doi: 10.1093/infdis/119.6.658. [DOI] [PubMed] [Google Scholar]
  3. Deysine M., Rosario E., Isenberg H. D. Acute hematogenous osteomyelitis: an experimental model. Surgery. 1976 Jan;79(1):97–99. [PubMed] [Google Scholar]
  4. Edwards J. E., Jr, Montgomerie J. Z., Foos R. Y., Shaw V. K., Guze L. B. Experimental hematogenous endophthalmitis caused by Candida albicans. J Infect Dis. 1975 Jun;131(6):649–657. doi: 10.1093/infdis/131.6.649. [DOI] [PubMed] [Google Scholar]
  5. Isenberg H. D., Reichler A., Wiseman D. Prototype of a fully automated device for determination of bacterial antibiotic susceptibility in the clinical laboratory. Appl Microbiol. 1971 Dec;22(6):980–986. doi: 10.1128/am.22.6.980-986.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kapral F. A. Clumping of Staphylococcus aureus in the peritoneal cavity of mice. J Bacteriol. 1966 Oct;92(4):1188–1195. doi: 10.1128/jb.92.4.1188-1195.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kapral F. A. Staphylococcus aureus: some host-parasite interactions. Ann N Y Acad Sci. 1974 Jul 31;236(0):267–276. doi: 10.1111/j.1749-6632.1974.tb41497.x. [DOI] [PubMed] [Google Scholar]
  8. Kobayashi F. Experimental infection with Pseudomonas aeruginosa in mice. I. The virulence of Pseudomonas aeruginosa for mice. Jpn J Microbiol. 1971 Jul;15(4):295–300. doi: 10.1111/j.1348-0421.1971.tb00584.x. [DOI] [PubMed] [Google Scholar]
  9. Kobayashi F. Experimental infection with Pseudomonas aeruginosa in mice. II. The fate of highly and low virulent strains in the peritoneal cavity and organs of mice. Jpn J Microbiol. 1971 Jul;15(4):301–307. [PubMed] [Google Scholar]
  10. MCRIPLEY R. J., GARRISON D. W. INCREASED SUSCEPTIBILITY OF BURNED RATS TO PSEUDOMONAS AERUGINOSA. Proc Soc Exp Biol Med. 1964 Feb;115:336–338. doi: 10.3181/00379727-115-28906. [DOI] [PubMed] [Google Scholar]
  11. Rottini G., Dri P., Soranzo M. R., Patriarca P. Correlation between phagocytic activity and metabolic response of polymorphonuclear leukocytes toward different strains of Escherichia coli. Infect Immun. 1975 Mar;11(3):417–423. doi: 10.1128/iai.11.3.417-423.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Sande M. A., Johnson M. L. Antimicrobial therapy of experimental endocarditis caused by Staphylococcus aureus. J Infect Dis. 1975 Apr;131(4):367–375. doi: 10.1093/infdis/131.4.367. [DOI] [PubMed] [Google Scholar]
  13. Saslaw S., Carlisle H. N., Moheimani M. Effect of vincristine sulfate on Pseudomonas infections in monkeys. Infect Immun. 1972 Aug;6(2):149–155. doi: 10.1128/iai.6.2.149-155.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Saymen D. G., Nathan P., Holder I. A., Hill E. O., Macmillan B. G. Infected surface wound: an experimental model and a method for the quantitation of bacteria in infected tissues. Appl Microbiol. 1972 Mar;23(3):509–514. doi: 10.1128/am.23.3.509-514.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Stieritz D. D., Holder I. A. Experimental studies of the pathogenesis of infections due to Pseudomonas aeruginosa: description of a burned mouse model. J Infect Dis. 1975 Jun;131(6):688–691. doi: 10.1093/infdis/131.6.688. [DOI] [PubMed] [Google Scholar]
  16. WALKER H. L., MASON A. D., Jr, RAULSTON G. L. SURFACE INFECTION WITH PSEUDOMONAS AERUGINOSA. Ann Surg. 1964 Aug;160:297–305. doi: 10.1097/00000658-196408000-00019. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Wiener S. L., Wiener R., Urivetzky M., Shafer S., Isenberg H. D., Janov C., Meilman E. The mechanism of action of a single dose of methylprednisolone on acute inflammation in vivo. J Clin Invest. 1975 Sep;56(3):679–689. doi: 10.1172/JCI108138. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Wiener S., Lendvai S., Rogers B., Urivetzky M., Meilman E. Nonimmune chemotaxis in vivo: inhibition by complement depletion with cobra factor. Am J Pathol. 1973 Dec;73(3):807–816. [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES