Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1976 Sep;14(3):613–617. doi: 10.1128/iai.14.3.613-617.1976

Immunodepression by Rowson-Parr virus in mice; lymphocyte markers and capping response of spleen and lymph node cells after infection.

M Bendinelli, H Friedman
PMCID: PMC420929  PMID: 1085752

Abstract

Infection with Rowson-Parr virus (RPV) induced a rapid reduction in the number of immunoglobulin-positive and theta antigen-positive cells detectable by immunofluorescence in the spleens of susceptible BALB/c mice. The changes produced by RPV infection in the lymph nodes were different, since the number of immunoglobulin-positive cells was increased and the proportion of theta-positive cells remained unchanged. However, the ability of immunoglobulin-bearing cells to redistribute their receptors into caps was reduced in both types of lymphoid tissue. A similar pattern of changes was produced by infection with Friend leukemia complex, from which RPV was originally obtained. These effects of RPV and Friend leukemia complex may contribute to the immunodepressed state of infected mice.

Full text

PDF
613

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bainbridge D. R., Bendinelli M. Circulation of lymphoid cells in mice infected with Friend leukemia virus. J Natl Cancer Inst. 1972 Sep;49(3):773–781. [PubMed] [Google Scholar]
  2. Bendinelli M., Campa M., Toniolo A. Immunodepression by Rowson-Parr virus in mice: effect of Rowson-Parr virus and Friend leukemia complex infections on contact sensitivity in susceptible and resistant mice. Infect Immun. 1975 May;11(5):1031–1037. doi: 10.1128/iai.11.5.1031-1037.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bendinelli M. Effect of Friend leukemia virus and Rowson-Parr virus on immunological maturation of mice. Infect Immun. 1971 Jul;4(1):1–5. doi: 10.1128/iai.4.1.1-5.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bendinelli M., Kaplan G. S., Friedman H. Reversal of leukemia virus-induced immunosuppression in vitro by peritoneal macrophages. J Natl Cancer Inst. 1975 Dec;55(6):1425–1432. doi: 10.1093/jnci/55.6.1425. [DOI] [PubMed] [Google Scholar]
  5. Bendinelli M., Nardini L. Immunodepression by Rowson-Parr virus in mice. I. Growth curves of Rowson-Parr virus and immunological relationships with Friend virus. Infect Immun. 1973 Feb;7(2):152–159. doi: 10.1128/iai.7.2.152-159.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bendinelli M., Nardini L. Immunodepression by Rowson-Parr virus in mice. II. Effect of Rowson-Parr virus infection on the antibody response to sheep red cells in vivo and in vitro. Infect Immun. 1973 Feb;7(2):160–166. doi: 10.1128/iai.7.2.160-166.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Carter R. L., Chesterman F. C., Rowson K. E., Salaman M. H., Wedderburn N. A new virus of minimal pathogenicity associated with Friend virus. II. Histological changes and immunodepressive effect. Int J Cancer. 1970 Jan 15;5(1):103–110. doi: 10.1002/ijc.2910050114. [DOI] [PubMed] [Google Scholar]
  8. Carter R. L., Chesterman F. C., Rowson K. E., Salaman M. H., Wedderburn N. Induction of lymphoma in BALB-c mice by Rowson-Parr virus (RPV). Int J Cancer. 1970 Sep 15;6(2):290–303. doi: 10.1002/ijc.2910060217. [DOI] [PubMed] [Google Scholar]
  9. Dawson P. J., Tacke R. B., Fieldsteel A. H. Relationship between Friend virus and an associated lymphatic leukaemia virus. Br J Cancer. 1968 Sep;22(3):569–576. doi: 10.1038/bjc.1968.67. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Dent P. B. Immunodepression by oncogenic viruses. Prog Med Virol. 1972;14:1–35. [PubMed] [Google Scholar]
  11. Dunham E. K., Unanue E. R., Benacerraf B. Antigen binding and capping by lymphocytes of genetic nonresponder mice. J Exp Med. 1972 Aug 1;136(2):403–408. doi: 10.1084/jem.136.2.403. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kateley J. R., Holderbach J., Friedman H. Leukemia virus-induced alteration of lymphocyte Ig surface receptors and the "capping" response of mouse spleen and lymph node cells. J Natl Cancer Inst. 1974 Oct;53(4):1135–1140. doi: 10.1093/jnci/53.4.1135. [DOI] [PubMed] [Google Scholar]
  13. Loor F., Forni L., Pernis B. The dynamic state of the lymphocyte membrane. Factors affecting the distribution and turnover of surface immunoglobulins. Eur J Immunol. 1972 Jun;2(3):203–212. doi: 10.1002/eji.1830020304. [DOI] [PubMed] [Google Scholar]
  14. Michaels L., Rowson K. E., Bird E. S. Electron microscopical study of Rowson-Parr virus infection in BALB-c mice. Int J Cancer. 1972 Jan 15;9(1):162–171. doi: 10.1002/ijc.2910090119. [DOI] [PubMed] [Google Scholar]
  15. POPE J. H. DETECTION OF AN AVIRULENT VIRUS APPARENTLY RELATED TO FRIEND VIRUS. Aust J Exp Biol Med Sci. 1963 Aug;41:349–362. doi: 10.1038/icb.1963.35. [DOI] [PubMed] [Google Scholar]
  16. RICH M. A., JOHNS L. W., Jr Morphology of an agent associated with a murine leukemia. Virology. 1963 Jun;20:373–376. doi: 10.1016/0042-6822(63)90128-4. [DOI] [PubMed] [Google Scholar]
  17. Riley V., Lilly F., Huerto E., Bardell D. Transmissible Agent Associated with 26 Types of Experimental Mouse Neoplasms. Science. 1960 Aug 26;132(3426):545–547. doi: 10.1126/science.132.3426.545. [DOI] [PubMed] [Google Scholar]
  18. Rowson K. E., Parr I. B. A new virus of minimal pathogenicity associated with Friend virus. I. Isolation by end-point dilution. Int J Cancer. 1970 Jan 15;5(1):96–102. doi: 10.1002/ijc.2910050113. [DOI] [PubMed] [Google Scholar]
  19. Steeves R. A., Eckner R. J., Mirand E. A., Priore R. L. Rapid assay of murine leukemia virus helper activity for Friend spleen focus-forming virus. J Natl Cancer Inst. 1971 Jun;46(6):1219–1228. [PubMed] [Google Scholar]
  20. Unanue E. R., Perkins W. D., Karnovsky M. J. Endocytosis by lymphocytes of complexes of anti-Ig with membrane-bound Ig. J Immunol. 1972 Feb;108(2):569–572. [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES