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. 1976 Sep;14(3):618–622. doi: 10.1128/iai.14.3.618-622.1976

Comparison of replication of adenovirus type 2 and type 4 in human lymphocyte cultures.

M Lambriex, J Van der Veen
PMCID: PMC420930  PMID: 965085

Abstract

Adenovirus type 2 was capable of replicating in purified lymphocyte cultures from human adenoid specimens. Phytohemagglutinin stimulation enhanced the replication of virus. Viral titers of 103 to 104 50% tissue culture infective doses per ml were reached after 4 to 8 days. Only 1 to 3 per 106 cells were found to produce virus. In contrast, there was no evidence that lymphocyte cultures could support the replication of adenovirus type 4. The life span of cultures infected with type 2 or 4 was not reduced. The possibility that lymphocytes infected with virus play a role in initiating natural, persisting adenovirus infections of human adenoids is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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