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. 1977 May;16(2):510–512. doi: 10.1128/iai.16.2.510-512.1977

Inhibition of small-intestinal sugar and amino acid transport by the enterotoxin of Shigella dysenteriae I.

H J Binder, D S Whiting
PMCID: PMC420982  PMID: 324910

Abstract

The enterotoxin of Shigella dysenteriae I produces fluid and electrolyte secretion in the rabbit ileum. These present studies were designed to evaluate nonelectrolyte transport in rabbit ileal mucosa exposed to Shigella enterotoxin. Both 10 mM galactose and 5 mM L-alanine absorptions were significantly impaired in enterotoxin-exposed ileal mucosa compared with control mucosa. L-Alanine influx was not imparied in two other secretory processes: that induced by cholera enterotoxin and hyperosmolarity. These studies provide evidence that both surgar and amino acid absorptions are diminished in the small intestine by the enterotoxin of S. dysenteriae I.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Banwell J. G., Sherr H. Effect of bacterial enterotoxins on the gastrointestinal tract. Gastroenterology. 1973 Sep;65(3):467–497. [PubMed] [Google Scholar]
  2. Binder H. J., Powell D. W. Bacterial enterotoxins and diarrhea. Am J Clin Nutr. 1970 Dec;23(12):1582–1587. doi: 10.1093/ajcn/23.12.1582. [DOI] [PubMed] [Google Scholar]
  3. Donowitz M., Binder H. J. Effect of enterotoxins of Vibrio cholerae, Escherichia coli, and Shigella dysenteriae type 1 on fluid and electrolyte transport in the colon. J Infect Dis. 1976 Aug;134(2):135–143. doi: 10.1093/infdis/134.2.135. [DOI] [PubMed] [Google Scholar]
  4. Donowitz M., Keusch G. T., Binder H. J. Effect of Shigella enterotoxin on electrolyte transport in rabbit ileum. Gastroenterology. 1975 Dec;69(6):1230–1237. [PubMed] [Google Scholar]
  5. Field M: Intestinal secretion: effect of cyclic AMP and its role in cholera. N Engl J Med. 1971 May 20;284(20):1137–1144. doi: 10.1056/NEJM197105202842008. [DOI] [PubMed] [Google Scholar]
  6. Grady G. F., Keusch G. T. Pathogenesis of bacterial diarrheas (second of two parts). N Engl J Med. 1971 Oct 14;285(16):891–900. doi: 10.1056/NEJM197110142851605. [DOI] [PubMed] [Google Scholar]
  7. Hendrix T. R., Banwell J. G. Pathogenesis of cholera. Gastroenterology. 1969 Dec;57(6):751–755. [PubMed] [Google Scholar]
  8. Hirschhorn N., Kinzie J. L., Sachar D. B., Northrup R. S., Taylor J. O., Ahmad S. Z., Phillips R. A. Decrease in net stool output in cholera during intestinal perfusion with glucose-containing solutions. N Engl J Med. 1968 Jul 25;279(4):176–181. doi: 10.1056/NEJM196807252790402. [DOI] [PubMed] [Google Scholar]
  9. Keusch G. T., Donta S. T. Classification of enterotoxins on the basis of activity in cell culture. J Infect Dis. 1975 Jan;131(1):58–63. doi: 10.1093/infdis/131.1.58. [DOI] [PubMed] [Google Scholar]
  10. Keusch G. T., Grady G. F., Mata L. J., McIver J. The pathogenesis of Shigella diarrhea. I. Enterotoxin production by Shigella dysenteriae I. J Clin Invest. 1972 May;51(5):1212–1218. doi: 10.1172/JCI106915. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Keusch G. T., Grady G. F., Takeuchi A., Sprinz H. The pathogenesis of shigella diarrhea. II. Enterotoxin-induced acute enteritis in the rabbit ileum. J Infect Dis. 1972 Jul;126(1):92–95. doi: 10.1093/infdis/126.1.92. [DOI] [PubMed] [Google Scholar]
  12. Klipstein F. A., Horowitz I. R., Engert R. F., Schnenk E. A. Effect of Klebsiella pneumoniae enterotoxin on intestinal transport in the rat. J Clin Invest. 1975 Oct;56(4):799–807. doi: 10.1172/JCI108158. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Klipstein F. A., Schenk E. A. Enterotoxigenic intestinal bacteria in tropical sprue. II. Effect of the bacteria and their enterotoxins on intestinal structure. Gastroenterology. 1975 Apr;68(4 Pt 1):642–655. [PubMed] [Google Scholar]
  14. PROHASKA J. V., JACOBSON M. J., DRAKE C. T., TAN T. L. Staphylococcus enterotoxin enteritis. Surg Gynecol Obstet. 1959 Jul;109(1):73–77. [PubMed] [Google Scholar]
  15. Powell D. W., Plotkin G. R., Solberg L. I., Catlin D. H., Maenza R. M., Formal S. B. Experimental diarrhea. II. Glucose-stimulated sodium and water transport in rat salmonella enterocolitis. Gastroenterology. 1971 Jun;60(6):1065–1075. [PubMed] [Google Scholar]
  16. Schultz S. G., Fuisz R. E., Curran P. F. Amino acid and sugar transport in rabbit ileum. J Gen Physiol. 1966 May;49(5):849–866. doi: 10.1085/jgp.49.5.849. [DOI] [PMC free article] [PubMed] [Google Scholar]

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