Abstract
The direct immunofluorescent antibody method revealed that Sendai virus, which was thought to be most prevalent in respiratory diseases in mice, infected the inner ear of mice when the virus was injected intracerebrally. Specific immunofluorescence that indicated the presence of antigens of Sendai virus was observed in both perilymphatic and endolymphatic structures. The routes of virus spread are discussed. This experimental study, using newborn mice and Sendai virus, may be useful for the investigation of the pathogenesis of viral labyrinthitis not only because of the high frequency of inner ear infection, but also because of long-time survivors which facilitate prolonged observation.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bordley J. E., Brookhouser P. E., Worthington E. L. Viral infections and hearing: a critical review of the literature, 1969-1970. Laryngoscope. 1972 Apr;82(4):557–577. doi: 10.1288/00005537-197204000-00002. [DOI] [PubMed] [Google Scholar]
- Davis G. L., Strauss M. Viral disease of the labyrinth. II. An experimental model using mouse cytomegalovirus. Ann Otol Rhinol Laryngol. 1973 Jul-Aug;82(4):584–594. doi: 10.1177/000348947308200415. [DOI] [PubMed] [Google Scholar]
- Davis L. E., Johnson R. T. Experimental viral infections of the inner ear. I. Acute infections of the newborn hamster labyrinth. Lab Invest. 1976 Apr;34(4):349–356. [PubMed] [Google Scholar]
- Davis L. E., Shurin S., Johnson R. T. Experimental viral labyrinthitis. Nature. 1975 Mar 27;254(5498):329–331. doi: 10.1038/254329a0. [DOI] [PubMed] [Google Scholar]
- MIMS C. A. Intracerebral injections and the growth of viruses in the mouse brain. Br J Exp Pathol. 1960 Feb;41:52–59. [PMC free article] [PubMed] [Google Scholar]
- Nagata I., Kimura Y., Ito Y., Tanaka T. Temperature-sensitive phenomenon of viral maturation observed in BHK cells persistently infected with HVJ. Virology. 1972 Aug;49(2):453–461. doi: 10.1016/0042-6822(72)90497-7. [DOI] [PubMed] [Google Scholar]
- Shimokata K., Nishiyama Y., Ito Y., Kimura Y., Nagata I. Pathogenesis of Sendai virus infection in the central nervous system of mice. Infect Immun. 1976 May;13(5):1497–1502. doi: 10.1128/iai.13.5.1497-1502.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Strauss M., Davis G. L. Viral disease of the labyrinth. I. Review of the literature and discussion of the role of cytomegalovirus in congenital deafness. Ann Otol Rhinol Laryngol. 1973 Jul-Aug;82(4):577–583. doi: 10.1177/000348947308200414. [DOI] [PubMed] [Google Scholar]