Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1977 Jun;16(3):827–831. doi: 10.1128/iai.16.3.827-831.1977

Evidence for a mouse pathogenicity locus in certain temperature-sensitive mutants of foot-and-mouth disease virus.

J Y Richmond
PMCID: PMC421037  PMID: 197007

Abstract

Serial tissue culture passaging of three foot-and-mouth disease temperature-sensitive mutants demonstrated the stability of their temperature sensitivity and mouse avirulence characteristics. Recovery of mouse-virulent temperature-sensitive viruses after passage of the mutants in mice suggested that these were not covariant expressions of the same locus, but were under the control of different genes.

Full text

PDF
827

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arlinghaus R. B., Polatnick J. The isolation of two enzyme-ribonucleic acid complexes involved in the synthesis of foot-and-mouth disease virus ribonucleic acid. Proc Natl Acad Sci U S A. 1969 Mar;62(3):821–828. doi: 10.1073/pnas.62.3.821. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Arlinghaus R. B., Syrewicz J. J., Loesch W. T., Jr RNA polymerase complexes from mengovirus infected cells. Arch Gesamte Virusforsch. 1972;38(1):17–28. doi: 10.1007/BF01241352. [DOI] [PubMed] [Google Scholar]
  3. BACHRACH H. L., CALLIS J. J., HESS W. R., PATTY R. E. A plaque assay for foot-and-mouth disease virus and kinetics of virus reproduction. Virology. 1957 Oct;4(2):224–236. doi: 10.1016/0042-6822(57)90060-0. [DOI] [PubMed] [Google Scholar]
  4. Bachrach H. L., Swaney J. B., Vande Woude G. F. Isolation of the structural polypeptides of foot-and-mouth disease virus and analysis of their C-terminal sequences. Virology. 1973 Apr;52(2):520–528. doi: 10.1016/0042-6822(73)90347-4. [DOI] [PubMed] [Google Scholar]
  5. CAMPBELL C. H. RELATIONSHIP OF DONOR AGE TO IN VITRO PRODUCTION OF FOOT-AND-MOUTH DISEASE VIRUS BY MOUSE KIDNEY CELLS. J Exp Med. 1965 Jan 1;121:69–83. doi: 10.1084/jem.121.1.69. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Campbell C. H. Influence of litter size, age, variation, and selective breeding of mice on susceptibility to foot-and-mouth disease virus. Am J Vet Res. 1968 Mar;29(3):685–691. [PubMed] [Google Scholar]
  7. Cooper P. D. Genetic analysis of animal viruses. New approaches and new vistas. Br Med Bull. 1967 May;23(2):155–160. doi: 10.1093/oxfordjournals.bmb.a070537. [DOI] [PubMed] [Google Scholar]
  8. Ghendon Y. Z., Marchenko A. T., Markushin S. G., Ghenkina D. B., Mikhejeva A. V., Rozina E. E. Correlation between TS phenotype and pathogenicity of some animal viruses. Arch Gesamte Virusforsch. 1973;42(2):154–159. doi: 10.1007/BF01270835. [DOI] [PubMed] [Google Scholar]
  9. MacKenzie J. S. Virulence of temperature-sensitive mutants of foot-and-mouth disease virus. Arch Virol. 1975;48(1):1–8. doi: 10.1007/BF01320560. [DOI] [PubMed] [Google Scholar]
  10. Mackenzie J. S. Virulence of temperature-sensitive mutants of influenza virus. Br Med J. 1969 Sep 27;3(5673):757–758. doi: 10.1136/bmj.3.5673.757. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Mills J., Chanock V., Chanock R. M. Temperature-sensitive mutants of influenza virus. I. Behavior in tissue culture and in experimental animals. J Infect Dis. 1971 Feb;123(2):145–157. doi: 10.1093/infdis/123.2.145. [DOI] [PubMed] [Google Scholar]
  12. Mirchamsy H., Rapp F. A new overlay for plaquing animal viruses. Proc Soc Exp Biol Med. 1968 Oct;129(1):13–17. doi: 10.3181/00379727-129-33237. [DOI] [PubMed] [Google Scholar]
  13. Pringle C. R., Slade W. R. The origin of hybrid variants derived from subtype strains of foot-and-mouth disease virus. J Gen Virol. 1968 May;2(3):319–329. doi: 10.1099/0022-1317-2-3-319. [DOI] [PubMed] [Google Scholar]
  14. Richmond J. Y., Polatnick J. Further studies of the physical and metabolic properties of foot-and-mouth disease virus temperature-sensitive mutants. Infect Immun. 1976 May;13(5):1392–1396. doi: 10.1128/iai.13.5.1392-1396.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Richmond J. Y. Production, isolation, and partial characterization of three foot-and-mouth disease virus temperature-sensitive mutants. Infect Immun. 1975 Jun;11(6):1291–1295. doi: 10.1128/iai.11.6.1291-1295.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Zygraich N., Lobmann M., Huygelen C. Inoculation of hamsters with a temperature sensitive (ts) mutant of parainfluenza 3 virus. J Hyg (Lond) 1972 Jun;70(2):229–234. doi: 10.1017/s0022172400022282. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES