Skip to main content
. 2014 Oct 22;6(10):4625–4639. doi: 10.3390/nu6104625

Table 6.

Association of nutrients with blood gene methylation.

Nutrients CD14 Et-1 HERV-w iNOS TNFα
β * SE p-value β * SE p-value β * SE p-value β * SE p-value β * SE p-value
Fiber, g/day −0.034 0.140 0.808 −0.028 0.058 0.628 0.054 0.039 0.164 0.160 0.408 0.695 −0.182 0.139 0.190
Protein, g/day −0.012 0.142 0.935 0.001 0.059 0.984 0.029 0.039 0.459 −0.328 0.413 0.429 −0.234 0.140 0.097
Carbohydrate, g/day −0.058 0.145 0.691 −0.016 0.060 0.786 −0.008 0.040 0.848 −0.134 0.424 0.752 −0.080 0.145 0.583
Lipids, g/day −0.186 0.141 0.190 0.001 0.059 0.982 0.007 0.040 0.865 0.095 0.416 0.819 −0.157 0.141 0.269
Monounsaturated fatty acid (MUFA), g/day −0.228 0.170 0.182 −0.033 0.063 0.599 0.009 0.046 0.837 −0.206 0.438 0.638 −0.208 0.166 0.213
Polyunsaturated fatty acid (PUFA), g/day −0.233 0.170 0.174 −0.044 0.065 0.495 0.009 0.046 0.850 −0.172 0.440 0.697 −0.199 0.168 0.239
PUFA n-3, g/day −0.186 0.143 0.196 0.001 0.059 0.987 0.009 0.040 0.825 0.147 0.420 0.726 −0.117 0.143 0.414
Saturated fatty acid, g/day 0.098 0.141 0.489 0.080 0.059 0.176 0.011 0.039 0.772 −0.693 0.409 0.092 −0.183 0.140 0.192
Cholesterol , mg/day −0.054 0.142 0.703 −0.022 0.059 0.713 0.021 0.039 0.590 −0.221 0.414 0.595 −0.278 0.139 0.048
Ascorbic acid, mg/day 0.230 0.138 0.098 −0.022 0.058 0.700 0.072 0.039 0.064 0.155 0.408 0.704 −0.146 0.139 0.295
Folic acid, μg/day 0.159 0.135 0.242 0.038 0.056 0.501 0.067 0.038 0.079 −0.203 0.398 0.610 −0.339 0.133 0.012
Alpha carotene, μg/day 0.050 0.170 0.770 −0.013 0.062 0.840 0.040 0.045 0.380 0.401 0.435 0.359 −0.190 0.165 0.253
Beta carotene, μg/day 0.170 0.169 0.316 0.027 0.063 0.673 0.088 0.044 0.051 0.210 0.436 0.631 −0.332 0.164 0.045
Carotenoids, μg/day 0.124 0.137 0.368 0.044 0.056 0.436 0.083 0.037 0.029 0.102 0.402 0.801 −0.331 0.135 0.015
Polyphenols and flavonoids, mg/day 0.156 0.173 0.370 −0.016 0.064 0.808 0.059 0.046 0.197 0.088 0.446 0.843 −0.152 0.169 0.371
Retinol, μg/day 0.103 0.137 0.453 0.026 0.056 0.645 0.071 0.038 0.063 0.026 0.403 0.949 −0.360 0.134 0.008
Tocopherols, mg/day −0.081 0.138 0.556 −0.001 0.057 0.987 0.044 0.038 0.253 −0.002 0.403 0.996 −0.205 0.137 0.136
Vitamin B12, μg/day 0.044 0.143 0.758 −0.018 0.059 0.763 0.028 0.040 0.487 −0.021 0.417 0.960 −0.153 0.142 0.281
Vitamin D, μg/day 0.228 0.138 0.101 0.078 0.057 0.171 0.008 0.039 0.828 −0.844 0.401 0.037 −0.180 0.137 0.193

Multivariable mixed-effect models adjusted for age, sex, BMI, smoking and % of neutrophils. * β regression coefficients were scaled to represent the increase in the dependent variable estimated for an increment equal to 1 SD in the independent variable.