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. 1977 Aug;17(2):274–277. doi: 10.1128/iai.17.2.274-277.1977

Effect of silica on the pathogenic distinction between herpes simplex virus type 1 and 2 hepatitis in mice.

S C Mogensen, H K Andersen
PMCID: PMC421113  PMID: 197016

Abstract

The role of macrophages in the difference in liver pathogenicity between herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in mice was investigated by selectively blocking the macrophage function of the mice by silica. Intravenous administration of 3 mg of silica 2 h before virus inoculation partially abolished the difference between the two virus types, as judged by macroscopic and microscopic examination of the livers and by virus isolation studies. Intraperitoneal inoculation of 50 mg of silical before virus seemed more effective in suppressing the macrophage function, since this treatment almost completely eliminated the difference in hepatotropism between HSV-1 and HSV-2 as assessed by the number and size of the lesions appearing in the liver. The final outcome of the infection, death from encephalitis, was, however, not influenced by macrophage blockade.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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