Table 1.
Summary of quantitative trait loci for gastrointestinal nematode resistance in sheep.
| Reference | QTL found or nearest marker | Chromosome number | Loci studied | Trait used |
|---|---|---|---|---|
| [12] | OARJMP29, McM130, McM357, TGLA67, OarVH130, McMA22, McM214, | 1, 3, 6, 11, 12, 20 | Genome-wide | FEC |
| [15] | BMS360, CSSM3, BM6465, CSAP39E, MCM158, RM96, CSSM37, MCM140, CMCA52, CSAP36E, CSSME76, MAF45, BM2818, FCB128 | X, 1, 6, 12 | 251 markers – genome-wide | strongyle faecal egg count (FEC), the coccidia faecal oocyst count (FOC) and a count of keds (Melophagus ovinus) |
| [23] | None | 20 | MHC | FEC |
| [25] | None | 20 | MHC | faecal scouring |
| [33] | OMHC1, OLADRB1, OLADRB2 | 20 | OMHC1, OLADRB1, OLADRB2 | faecal egg count (FEC), blood packed cell volume (PCV), antibody (AB) levels, serum proteins (SP) and blood eosinophil count (EOS) |
| [37] | o(IFN)-γ | 3 | o(IFN)-γ | FEC, IgA |
| [38] | BM81124, BM3215, BM3215, BM9202, ILSTS65, ILSTS42 | 8, 11, 23 | Genome-wide | FEC, total serum IgE, serum IgGspecific for the T. colubriformis L3 larvae |
| [40] | IFNG, MHC | 2, 3, 14, 20 | 139 Microsatellite markers on Chr 1, 2, 3, 5, 14, 18, 20, 21 | IgA, FEC |
| [43] | EPCDV010, ILSTS044 | 1 | 18 microsatellite markers | FEC, Nr adult larvae |
| [57] | OMCH1 | 20 | MHC Class I | - |
| [58] | OLADRB1 | 20 | MHC Class II | - |
| [62] | None | 20 | MHC Class II | FEC |
| [63] | OarCP73, DYMS1, BM1815 | 20 | MHC | haemotocrit level, FEC, igL |
| [65] | Ovar-DQA1 | 20 | MHC Class II | Transcription profiles |
| [77] | Between AC113228 & ILSTS62 and CP26 & BMS648; between markers URB060 & MCMA13; between markers ILSTS28 & ILSTS45; between markers DU363924 & BMS2572 and MCM37 & MCM137 | 1, 3, 4 | 223 markers in Genome scan | FEC |
| [85] | 16 genomic regions including CD53, CHI3L2, CHIA, DENND2D, RELN, NSUN2, HRH1 | 1, 4, 16, 19 | Genome-wide | Selection signatures |
| [88] | Not specified | 5, 12, 13, 21 | 50 K SNP chip | FEC |
| [94] | OLADRB | 3 | MHC | FEC |
| [95] | IFNG region BL4; BMS1617 | 3 | fine mapping | FEC |
| [97] | INRA132 CP101 | 20 | BM1818, OarCP73, OarHH56, DYA, OLADRB, CP101, OMHC1, DQA2, DQA1, TFAP2A, DQBA27, Bf94_1, and INRA132 | FEC |
| [102] | IRF3, TGF-B1 among others | 4, 12, 14, 19, 20, as well as OAR1, 3, 4, 5, 7, 12, 19, 20 and 24 at suggestive level | Meta-analysis – Illumina OvineSNP50 BeadChip | FEC |
| [107] | s39968, OAR12_62301297, OAR12_62347621, OAR12_62371899 | 7, 9, 14, 15, 21, 4, 5, 6, 8, 12, 17, 18, 19, 23, 21, 13 | 160 microsatellite markers were used as well as the Illumina OvineSNP50 BeadChip | FEC, PCV, worm burden, length of females, IgG, and pepsinogen concentration |
| [111] | MHC-DRB1 | 20 | MHC-DRB1 | FEC |
| [119] | MHC-DRB1 | 20 | MHC-DRB1 | FEC, lymphocyte antigen |