Abstract
Mice sensitized intravenously with 300 microgram of BCG cell walls in Drakeol-Tween 80 and challenged intravenously 3 weeks later with 50 mg of old tuberculin released migration inhibitory factor (MIF) into the circulating blood in quantities that could be detected in serum dilutions of 1:64 to 1:128. When thymus-derived lymphocytes (T-cells) were absent at the time of sensitization, as in neonatally thymectomized mice or in athymic nude mice, detectable amounts of MIF were not formed. Sensitized mice treated with either anti-theta serum or anti-bone marrow-derived lymphocyte (B-cell) serum before intravenous challenge with old tuberculin released reduced amounts of MIF into the circulation. Mice lethally irradiated, reconstituted with B-cells, sensitized with BCG cell walls, and then challenged intravenously 3 weeks later with old tuberculin did not release MIF into the circulation. When T-cells were injected at least 10 days before challenge, however, MIF appeared.
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- Altman L. C., Kirchner H. The production of a monocyte chemotactic factor by agammaglobulinemic chicken spleen cells. J Immunol. 1972 Nov;109(5):1149–1151. [PubMed] [Google Scholar]
- Argyris B. F., Cooney A. Effects of anti-T cell (theta) and anti-B cell (beta) serum on the immune response in mice. Immunol Commun. 1972;1(5):453–470. doi: 10.3109/08820137209022956. [DOI] [PubMed] [Google Scholar]
- Neta R., Salvin S. B. Specific suppression of delayed hypersensitivity: the possible presence of a suppressor B cell in the regulation of delayed hypersensitivity. J Immunol. 1974 Dec;113(6):1716–1725. [PubMed] [Google Scholar]
- Niederhuber J. E. An improved method for preparing anti-B lymphocyte serum. Nat New Biol. 1971 Sep 15;233(37):86–87. doi: 10.1038/newbio233086a0. [DOI] [PubMed] [Google Scholar]
- REIF A. E., ALLEN J. M. THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES. J Exp Med. 1964 Sep 1;120:413–433. doi: 10.1084/jem.120.3.413. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rocklin R. E., MacDermott R. P., Chess L., Schlossman S. F., David J. R. Studies on mediator production by highly purified human T and B lymphocytes. J Exp Med. 1974 Nov 1;140(5):1303–1316. doi: 10.1084/jem.140.5.1303. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Salvin S. B., Neta R. A possible relationship between delayed hypersensitivity and cell-mediated immunity. Am Rev Respir Dis. 1975 Apr;111(4):373–377. doi: 10.1164/arrd.1975.111.4.373. [DOI] [PubMed] [Google Scholar]
- Salvin S. B., Nishio J. Communications. "In vitro" cell reactions in delayed hypersensitivity. J Immunol. 1969 Jul;103(1):138–141. [PubMed] [Google Scholar]
- Salvin S. B., Ribi E., Granger D. L., Youngner J. S. Migration inhibitory factor and type II interferon in the circulation of mice sensitized with mycobacterial components. J Immunol. 1975 Jan;114(1 Pt 2):354–359. [PubMed] [Google Scholar]
- Salvin S. B., Youngner J. S., Lederer W. H. Migration inhibitory factor and interferon in the circulation of mice with delayed hypersensitivity. Infect Immun. 1973 Jan;7(1):68–75. doi: 10.1128/iai.7.1.68-75.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sugane K., Kasahara T., Shioiri-Nakano K. Release of migration inhibitory factor from mouse T and B cells activated by insoluble phytomitogens. Jpn J Exp Med. 1975 Feb;45(1):19–24. [PubMed] [Google Scholar]
- Wahl S. M., Iverson G. M., Oppenheim J. J. Induction of guinea pig B-cell lymphokine synthesis by mitogenic and nonmitogenic signals to Fc, Ig, and C3 receptors. J Exp Med. 1974 Dec 1;140(6):1631–1645. doi: 10.1084/jem.140.6.1631. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Youngner J. S., Salvin S. B. Production and properties of migration inhibitory factor and interferon in the circulation of mice with delayed hypersensitivity. J Immunol. 1973 Dec;111(6):1914–1922. [PubMed] [Google Scholar]