Table 2.
Logistic regression analysis of factors associated with being in a phylogenetic pair/cluster for participants with HCV genotype 1a or 3a in the VIDUS cohort, 1996-2012, Vancouver, Canada.
| Characteristic | Overall | Not cluster | Pair/cluster | Membership in pair/cluster (n ≥
2) |
|||||
|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | ||||||||
| Total n (%) | (n=501) | (n = 345) | (n=156) | Odds ratio | 95% CI | P | Odds ratio | 95% CI | P |
| Female sex (vs. male sex) | 121 (24%) | 78 (23%) | 43 (28%) | 1.30 | 0.85 - 2.01 | 0.231 | - | - | - |
| Age <40 years (vs. ≥40 years) | 340 (68%) | 221 (64%) | 119 (76%) | 1.80 | 1.17 - 2.77 | 0.007 | 1.63 | 1.05 - 2.53 | 0.028 |
| High school education or higher (vs. less than high school)* | 91 (18%) | 59 (17%) | 32 (21%) | 1.26 | 0.78 - 2.03 | 0.350 | - | - | - |
| Unstable housing (vs. stable)† | 352 (70%) | 246 (71%) | 106 (68%) | 0.85 | 0.57 - 1.28 | 0.447 | - | - | - |
| HCV Genotype 3a | 190 (38%) | 125 (36%) | 65 (42%) | 1.26 | 0.85 - 1.85 | 0.246 | - | - | - |
| Recent HCV seroconversion (vs. not) | 31 (6%) | 16 (5%) | 15 (10%) | 2.34 | 1.11 - 4.92 | 0.025 | 3.05 | 1.4 - 6.66 | 0.005 |
| HIV infection (vs. none)† | 131 (26%) | 79 (23%) | 52 (33%) | 1.68 | 1.11 - 2.55 | 0.014 | 1.82 | 1.18 - 2.81 | 0.006 |
| Currently enrolled in methadone treatment (vs. yes) | 64 (13%) | 47 (14%) | 17 (11%) | 0.77 | 0.43 - 1.39 | 0.386 | - | - | - |
| Syringe borrowing (vs. none)† | 205 (41%) | 130 (38%) | 75 (48%) | 1.53 | 1.04 - 2.24 | 0.029 | 1.59 | 1.07 - 2.36 | 0.022 |
| Crack use (vs. none)† | 123 (25%) | 88 (26%) | 35 (22%) | 0.84 | 0.54 - 1.32 | 0.460 | - | - | - |
| Cocaine injecting (vs. none)† | 424 (85%) | 286 (83%) | 138 (88%) | 1.58 | 0.9 - 2.78 | 0.112 | - | - | - |
| Heroin injecting (vs. none)† | 370 (74%) | 255 (74%) | 115 (74%) | 0.99 | 0.64 - 1.52 | 0.963 | - | - | - |
| Speedball injecting (vs. none)† | 213 (43%) | 140 (41%) | 73 (47%) | 1.29 | 0.88 - 1.88 | 0.193 | - | - | - |
Percentages indicate column percentages
*
At the time of enrolment
†
in the last 6 months prior to enrolment.
Abbreviations: HIV = human immunodeficiency virus; HCV hepatitis C virus.