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. 2014 Oct 23;16(10):771–788. doi: 10.1016/j.neo.2014.08.013

Figure 9.

Figure 9

Microarchitecture of intratumoral angiogenic vasculature depends on Mmp9 host genotype. (A) Top: LLC tumors from WT (left) and Mmp9-KO (right) mice were stained for CD31 (red). Bars, 100 μm (top) and 50 μm (bottom). (B) Density of CD31-positive lumen-less capillaries and lumen-containing blood vessels was quantified in a total of 45 to 55 tumor images taken from six to eight individual WT and Mmp9-KO tumors from three independent experiments. The data are presented as fraction of particular vessel type versus total number of vessels. ***P< .001. (C) Distribution of lumen-containing blood vessels according to their lumen diameter. Fractions of intratumoral CD31-positive blood vessels with lumen diameters of < 10 μm, 11 to 20 μm, and > 21 μm were calculated against total number of lumen-containing vessels (LC). Two bars on the right represent fractions of blood vessels with lumens of > 11 μm calculated against total number of intratumoral blood vessels. *P < .05, **P < .005, ***P < .0001.