Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1977 Nov;18(2):342–347. doi: 10.1128/iai.18.2.342-347.1977

Interaction between cyclic nucleotides and herpes simplex viruses: productive infection.

T L Stanwick, R W Anderson, A J Nahmias
PMCID: PMC421237  PMID: 200559

Abstract

Infection of human fibroblasts and HEp-2 cells with herpes simplex virus type 1 (HSV-1) produced a decrease in the intracellular levels of cyclic adenosine 5'- monophosphate (cAMP) and a concomitant increase in the cyclic guanosine 5'- monophosphate (cGMP) levels. In both cell cultures, changes in cyclic nucleotide levels were first observed at 6 h after viral inoculation and were maximal at 12 h. In human fibroblasts, the addition of theophylline, dibutyryl cAMP, or papaverine (cAMP-enhancing compounds) decreased significantly the yield of HSV-1, whereas the addition of insulin or dibutyryl cGMP (cGMP-enhancing compounds) increased the viral yield. In HEp-2 cells, only theophylline decreased the yield of HSV-1, and the cGMP-enhancing compounds had no apparent effect. Cyclic nucleotide enhancing compounds exhibited their effect only if added to either cell culture within the first 3 h after inoculation with HSV-1.

Full text

PDF
342

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson W. B., Johnson G. S., Pastan I. Transformation of chick-embryo fibroblasts by wild-type and temperature-sensitive Rous sarcoma virus alters adenylate cyclase activity. Proc Natl Acad Sci U S A. 1973 Apr;70(4):1055–1059. doi: 10.1073/pnas.70.4.1055. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Baringer J. R., Swoveland P. Persistent herpes simplex virus infection in rabbit trigeminal ganglia. Lab Invest. 1974 Feb;30(2):230–240. [PubMed] [Google Scholar]
  3. Baringer J. R., Swoveland P. Recovery of herpes-simplex virus from human trigeminal ganglions. N Engl J Med. 1973 Mar 29;288(13):648–650. doi: 10.1056/NEJM197303292881303. [DOI] [PubMed] [Google Scholar]
  4. Bastian F. O., Rabson A. S., Yee C. L., Tralka T. S. Herpesvirus hominis: isolation from human trigeminal ganglion. Science. 1972 Oct 20;178(4058):306–307. doi: 10.1126/science.178.4058.306. [DOI] [PubMed] [Google Scholar]
  5. Bourne H. R., Lichtenstein L. M., Melmon K. L., Henney C. S., Weinstein Y., Shearer G. M. Modulation of inflammation and immunity by cyclic AMP. Science. 1974 Apr 5;184(4132):19–28. doi: 10.1126/science.184.4132.19. [DOI] [PubMed] [Google Scholar]
  6. Costa J., Yee C., Troost T., Rabson A. S. Effect of dexamethasone on herpes simplex virus type 2 infection in vitro. Nature. 1974 Dec 20;252(5485):745–746. doi: 10.1038/252745a0. [DOI] [PubMed] [Google Scholar]
  7. Duff R., Rapp F. Properties of hamster embryo fibroblasts transformed in vitro after exposure to ultraviolet-irradiated herpes simplex virus type 2. J Virol. 1971 Oct;8(4):469–477. doi: 10.1128/jvi.8.4.469-477.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hill T. J., Blyth W. A. An alternative theory of herpes-simplex recurrence and a possible role for prostaglandins. Lancet. 1976 Feb 21;1(7956):397–399. doi: 10.1016/s0140-6736(76)90220-8. [DOI] [PubMed] [Google Scholar]
  9. Ida S., Hooks J. J., Siraganian R. P., Notkins A. L. Enhancement of IgE-mediated histamine release from human basophils by viruses: role of interferon. J Exp Med. 1977 Apr 1;145(4):892–906. doi: 10.1084/jem.145.4.892. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Johnson G. S., Friedman R. M., Pastan I. Restoration of several morphological characteristics of normal fibroblasts in sarcoma cells treated with adenosine-3':5'-cyclic monphosphate and its derivatives. Proc Natl Acad Sci U S A. 1971 Feb;68(2):425–429. doi: 10.1073/pnas.68.2.425. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. KLAINER L. M., CHI Y. M., FREIDBERG S. L., RALL T. W., SUTHERLAND E. W. Adenyl cyclase. IV. The effects of neurohormones on the formation of adenosine 3',5'-phosphate by preparations from brain and other tissues. J Biol Chem. 1962 Apr;237:1239–1243. [PubMed] [Google Scholar]
  12. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  13. Otten J., Bader J., Johnson G. S., Pastan I. A mutation in a rous sarcoma virus gene that controls adenosine 3',5'-monophosphate levels and transformation. J Biol Chem. 1972 Mar 10;247(5):1632–1633. [PubMed] [Google Scholar]
  14. Pastan I. The effect of dibutyryl cyclic 3',5'-AMP on the thyroid. Biochem Biophys Res Commun. 1966 Oct 5;25(1):14–16. doi: 10.1016/0006-291x(66)90632-2. [DOI] [PubMed] [Google Scholar]
  15. Peery C. V., Johnson G. S., Pastan I. Adenyl cyclase in normal and transformed fibroblasts in tissue culture. Activation by prostaglandins. J Biol Chem. 1971 Sep 25;246(18):5785–5790. [PubMed] [Google Scholar]
  16. ROIZMAN B. The programming of herpes virus multiplication in doubly-infected and in puromycin-treated cells. Proc Natl Acad Sci U S A. 1963 Feb 15;49:165–171. doi: 10.1073/pnas.49.2.165. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. ROIZMAN B. The role of hormones in viral infection. II. Acceleration of viral adsorption and penetration into cells treated with thyroid hormone in vitro. Proc Natl Acad Sci U S A. 1962 Jun 15;48:973–977. doi: 10.1073/pnas.48.6.973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. ROIZMAN B. The role of hormones in viral infections. I. Suppression of viral adsorption and penetration into cells treated with parathyroid hormone in vitro. Proc Natl Acad Sci U S A. 1962 May 15;48:795–803. doi: 10.1073/pnas.48.5.795. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Rapp F., Buss E. R. Comparison of herpes simplex virus isolates using a quantitative selection assay for transformation. Intervirology. 1975;6(2):72–82. doi: 10.1159/000149458. [DOI] [PubMed] [Google Scholar]
  20. Raska K., Jr Cycl AMP in Gl-arrested BHK21 cells infected with adenovirus type 12. Biochem Biophys Res Commun. 1973 Jan 4;50(1):35–41. doi: 10.1016/0006-291x(73)91059-0. [DOI] [PubMed] [Google Scholar]
  21. Rein A., Carchman R. A., Johnson G. S., Pastan I. Simian virus 40 rapidly lowers cAMP levels in mouse cells. Biochem Biophys Res Commun. 1973 Jun 8;52(3):899–904. doi: 10.1016/0006-291x(73)91022-x. [DOI] [PubMed] [Google Scholar]
  22. Roizman B. The herpesviruses--a biochemical definition of the group. Curr Top Microbiol Immunol. 1969;49:3–79. [PubMed] [Google Scholar]
  23. Smith B. J., Defendi V., Wigglesworth N. M. The effect of dibutyryl cyclic AMP on transformation by oncogenic viruses. Virology. 1973 Jan;51(1):230–232. doi: 10.1016/0042-6822(73)90383-8. [DOI] [PubMed] [Google Scholar]
  24. Stevens J. G. Latent herpes simplex virus and the nervous system,. Curr Top Microbiol Immunol. 1975;70:31–50. doi: 10.1007/978-3-642-66101-3_2. [DOI] [PubMed] [Google Scholar]
  25. Sydiskis R. J., Roizman B. Polysomes and protein synthesis in cells infected with a DNA virus. Science. 1966 Jul 1;153(3731):76–78. doi: 10.1126/science.153.3731.76. [DOI] [PubMed] [Google Scholar]
  26. Walz M. A., Price R. W., Notkins A. L. Latent ganglionic infection with herpes simplex virus types 1 and 2: viral reactivation in vivo after neurectomy. Science. 1974 Jun 14;184(4142):1185–1187. doi: 10.1126/science.184.4142.1185. [DOI] [PubMed] [Google Scholar]
  27. Zimmerman J. E., Jr, Glaser R., Rapp F. Effect of dibutyryl cyclic AMP on the induction of Epstein-Barr virus in hybrid cells. J Virol. 1973 Dec;12(6):1442–1445. doi: 10.1128/jvi.12.6.1442-1445.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Zimmerman J. E., Jr, Raska K., Jr Inhibition of adenovirus type 12 induced DNA synthesis in G1-arrested BHK21 cells by dibutyryl adenosine cyclic 3':5'-monophosphate. Nat New Biol. 1972 Oct 4;239(92):145–147. doi: 10.1038/newbio239145a0. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES