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. 1977 Jan;15(1):239–244. doi: 10.1128/iai.15.1.239-244.1977

Cell-mediated immunity to Sendai virus infection in mice.

M J Anderson, D R Bainbridge, J R Pattison, R B Heath
PMCID: PMC421354  PMID: 188766

Abstract

The development of a cell-mediated immune response to Sendai virus infection in mice was examined by the use of a 51Cr release assay of cytotoxicity. A low level of "background cytotoxicity" to Sendai virus-infected L cells was found in the spleens of uninfected CBA mice. Spleen cells from Sendai-infected mice showed an elevated level of cytotoxicity against these target cells for a period of 5 weeks, commencing 4 days after infection of the mice. A more transient response was observed in the spleens of mice infected with a serologically distinct virus, the Kunz strain of influenza. This cross-reacting, cell-mediated immune response was intermediate between that observed in unsensitized and Sendai-sensitized spleen cells. The relevance of these cell-mediated immune responses to respiratory tract virus infections is discussed.

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Selected References

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