Abstract
C3H/Bi mice developed autoantibodies after repeated inoculations of isolated membranes from primary tissue cultures of a syngeneic ascites lymphoma in which Newcastle disease virus had grown. This was in addition to the tumor transplantation resistance and cytotoxic antibodies previously demonstrated. The complement-fixing antibodies were completely removed from sera by adsorption with ascites tumor cells but only partially by normal mouse liver powder or C3H/Bi erythrocytes. With continued immunization, antibodies to deoxynucleoprotein and heterophile reagins also appeared. After several months, mice showing these serological reactions died with a wasting disease characterized by loss of lymphoid tissue and scarred, atrophied kidneys. No significant antibody response or autoimmune disease occurred in mice receiving membranes from uninfected syngeneic ascites lymphoma.
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Selected References
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- Boone C. W. Augmented immunogenicity of tumor cell homogenates produced by infection with influenza virus. Natl Cancer Inst Monogr. 1972 Dec;35:301–307. [PubMed] [Google Scholar]
- Boone C. W., Paranjpe M., Orme T., Gillette R. Virus-augmented tumor transplantation antigens: evidence for a Helper antigen mechanism. Int J Cancer. 1974 Apr 15;13(4):543–551. doi: 10.1002/ijc.2910130414. [DOI] [PubMed] [Google Scholar]
- Eaton M. D., Heller J. A., Scala A. R. Enhancement of lymphoma cell immunogenicity by infection with nononcogenic virus. Cancer Res. 1973 Dec;33(12):3293–3298. [PubMed] [Google Scholar]
- Eaton M. D., Levinthal J. D., Scala A. R. Contribution of antiviral immunity to oncolysis by Newcastle disease virus in a murine lymphoma. J Natl Cancer Inst. 1967 Dec;39(6):1089–1097. [PubMed] [Google Scholar]
- Eaton M. D., Scala A. R. Removal of cell-associated myxovirus by antibody. Proc Soc Exp Biol Med. 1971 Oct;138(1):186–189. doi: 10.3181/00379727-138-35858. [DOI] [PubMed] [Google Scholar]
- Eaton M. D., Scala A. R. Species source of complement in viral-immune and other cytolytic reactions. Proc Soc Exp Biol Med. 1970 Feb;133(2):615–619. doi: 10.3181/00379727-133-34529. [DOI] [PubMed] [Google Scholar]
- KUNKEL H. G., TAN E. M. AUTOANTIBODIES AND DISEASE. Adv Immunol. 1964;27:351–395. doi: 10.1016/s0065-2776(08)60711-7. [DOI] [PubMed] [Google Scholar]
- Lindenmann J., Klein P. A. Viral oncolysis: increased immunogenicity of host cell antigen associated with influenza virus. J Exp Med. 1967 Jul 1;126(1):93–108. doi: 10.1084/jem.126.1.93. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nowinski R. C., Klein P. A. Anomalous reactions of mouse alloantisera with cultured tumor cells. II. Cytotoxicity is caused by antibodies to leukemia viruses. J Immunol. 1975 Nov;115(5):1261–1268. [PubMed] [Google Scholar]
- Oldstone M. B., Aoki T., Dixon F. J. Activation of spontaneous murine leukemia virus-related antigen by lymphocytic choriomeningitis virus. Science. 1971 Nov 19;174(4011):843–845. doi: 10.1126/science.174.4011.843. [DOI] [PubMed] [Google Scholar]
- Phillips S. M., Hirsch M. S., André-Schwartz J., Solnik C., Black P., Schwartz R. S., Merrill J. P., Carpenter C. B. Cellular immunity in the mouse. V. Further studies on leukemia virus activation in allogeneic reactions of mice: stimulatory parameters. Cell Immunol. 1975 Jan;15(1):169–179. doi: 10.1016/0008-8749(75)90173-2. [DOI] [PubMed] [Google Scholar]
- Sauter C., Bächi T., Lindenmann J. Human mammary carcinoma cell line: infection by an avian myxovirus as a prerequisite for immunopotentiation. Eur J Cancer. 1975 Jan;11(1):59–63. doi: 10.1016/0014-2964(75)90038-9. [DOI] [PubMed] [Google Scholar]
- Simmons R. L., Rios A. Immunotherapy of cancer: immunospecific rejection of tumors in recipients of neuraminidase-treated tumor cells plus BCG. Science. 1971 Nov 5;174(4009):591–593. doi: 10.1126/science.174.4009.591. [DOI] [PubMed] [Google Scholar]
- Teague P. O., Friou G. J., Myers L. L. Anti-nuclear antibodies in mice. I. Influence of age and possible genetic factors on spontaneous and induced responses. J Immunol. 1968 Oct;101(4):791–798. [PubMed] [Google Scholar]
- Wang M., Halliday W. J. Immune responses of mice to iodoacetate-treated Ehrlich ascites tumour cells. Br J Cancer. 1967 Jun;21(2):346–352. doi: 10.1038/bjc.1967.39. [DOI] [PMC free article] [PubMed] [Google Scholar]