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. 1977 Feb;15(2):402–409. doi: 10.1128/iai.15.2.402-409.1977

Persistence of cytomegalovirus in human lymphoblasts and peripheral leukocyte cultures.

S St Jeor, A Weisser
PMCID: PMC421382  PMID: 191399

Abstract

The in vitro susceptibility of human peripheral lymhpocytes and lymphoblastoid (F265) cells to infection by human cytomegalovirus was examined. Infection of these cell types with cytomegalovirus resulted in a persistent type of infection rather than the typical growth curve observed with permissive fibroblastic cells. When infection of peripheral lymphocytes was associated with a blastogenic response, the virus persisted for a longer time and at a higher titer than in cells in which a blastogenic response did not occur. Autoradiographic studies and infectious-center assays indicated that only a small number of cells, resembling lymphocytes, were involved in virus persistence. Whether or not the persistence of the virus indicates release of input virus or synthesis or new virus was not determined.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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