Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1977 Mar;15(3):733–736. doi: 10.1128/iai.15.3.733-736.1977

Lack of protection afforded by ribonucleic acid preparations from Mycobacterium tuberculosis against Mycobacterium leprae infections in mice.

C C Shepard, A Y Youmans, G P Youmans
PMCID: PMC421431  PMID: 404242

Abstract

Mycobacterial ribonucleic acid preparations from H37Ra, an attenuated strain of Mycobacterium tuberculosis, provide their usual marked protection against M. tuberculosis challenge; however, they provided no protection against Mycobacterium leprae challenge. Suspensions of intact H37Ra were not effective against M. leprae. Suspensions of BCG gave their usual distinct protection against M. leprae challenge.

Full text

PDF
733

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Paul R. C., Stanford J. L., Carswell J. W. Multiple skin testing in leprosy. J Hyg (Lond) 1975 Aug;75(1):57–68. doi: 10.1017/s0022172400047069. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. SHEPARD C. C. VACCINATION AGAINST EXPERIMENTAL INFECTION WITH MYCOBACTERIUM LEPRAE. Am J Epidemiol. 1965 Mar;81:150–163. doi: 10.1093/oxfordjournals.aje.a120504. [DOI] [PubMed] [Google Scholar]
  3. Shepard C. C. A comparison of the effectiveness of two freeze-dried BCG vaccines against Mycobacterium leprae in mice. Bull World Health Organ. 1968;38(1):135–140. [PMC free article] [PubMed] [Google Scholar]
  4. Shepard C. C. Vaccination against human leprosy bacillus infections of mice: protection by BCG given during the incubation period. J Immunol. 1966 Feb;96(2):279–283. [PubMed] [Google Scholar]
  5. Shepard C. C. Vaccination of mice against M. leprae infection. Int J Lepr Other Mycobact Dis. 1976 Jan-Jun;44(1-2):222–226. [PubMed] [Google Scholar]
  6. Shepard C. C., Van Landingham R., Walker L. L. Immunity to Mycobacterium leprae infections in mice stimulated by M. leprae, BCG, and graft-versus-host reactions. Infect Immun. 1976 Oct;14(4):919–928. doi: 10.1128/iai.14.4.919-928.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Thomas D. W., Weiss E. Response of mice to injection of ribosomal fraction from group B Neisseria meningitidis. Infect Immun. 1972 Sep;6(3):355–363. doi: 10.1128/iai.6.3.355-363.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Thompson H. C., Snyder I. S. Protection against pneumococcal infection by a ribosomal preparation. Infect Immun. 1971 Jan;3(1):16–23. doi: 10.1128/iai.3.1.16-23.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Venneman M. R., Bigley N. J. Isolation and partial characterization of an immunogenic moiety obtained from Salmonella typhimurium. J Bacteriol. 1969 Oct;100(1):140–148. doi: 10.1128/jb.100.1.140-148.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Winston S. H., Berry L. J. Antibacterial immunity induced by ribosomal vaccines. J Reticuloendothel Soc. 1970 Jul;8(1):13–24. [PubMed] [Google Scholar]
  11. YOUMANS A. S., YOUMANS G. P. IMMUNOGENIC ACTIVITY OF A RIBOSOMAL FRACTION OBTAINED FROM MYCOBACTERIUM TUBERCULOSIS. J Bacteriol. 1965 May;89:1291–1298. doi: 10.1128/jb.89.5.1291-1298.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Youmans A. S., Youmans G. P. Factors affecting immunogenic activity of mycobacterial ribosomal and ribonucleic acid preparations. J Bacteriol. 1969 Jul;99(1):42–50. doi: 10.1128/jb.99.1.42-50.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES