Abstract
Antibodies against Rickettsia tsutsugamushi detected by the indirect fluorescent-antibody test (IFAT) were present in most rats trapped from a human focus of scrub typhus in the Philippines. Rickettsiae were isolated only from rats with positive IFATs. Naturally acquired antibodies persisted for at least 11 months, and antibodies resulting from experimental infections of rats persisted for at least 7 months. A common Philippine rodent, Rattus mindanensis, tolerated experimental infections with both local and standard Karp strains of R. tsutsugamushi, and such infections always produced a positive IFAT.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BOZEMAN F. M., ELISBERG B. L. Serological diagnosis of scrub typhus by indirect immunofluorescence. Proc Soc Exp Biol Med. 1963 Mar;112:568–573. doi: 10.3181/00379727-112-28107. [DOI] [PubMed] [Google Scholar]
- Gan E., Cadigan F. C., Jr, Walker J. S. Filter paper collection of blood for use in a screening and diagnostic test for scrub typhus using the IFAT. Trans R Soc Trop Med Hyg. 1972;66(4):588–593. doi: 10.1016/0035-9203(72)90304-5. [DOI] [PubMed] [Google Scholar]
- Muul I., Liat L. B., Walker J. S. Mammals and scrub typhus ecology in peninsular Malaysia. Trans R Soc Trop Med Hyg. 1975;69(1):121–130. doi: 10.1016/0035-9203(75)90021-8. [DOI] [PubMed] [Google Scholar]
- Muul I., Lim B. L., Gan E. Scrub typhus antibody in mammals in three habitats in Sabah. Southeast Asian J Trop Med Public Health. 1974 Mar;5(1):80–84. [PubMed] [Google Scholar]
- Traub R., Wisseman C. L., Jr, Jones M. R., O'Keefe J. J. The acquisition of Rickettsia tsutsugamushi by chiggers (trombiculid mites) during the feeding process. Ann N Y Acad Sci. 1975;266:91–114. doi: 10.1111/j.1749-6632.1975.tb35091.x. [DOI] [PubMed] [Google Scholar]
- Traub R., Wisseman C. L., Jr The ecology of chigger-borne rickettsiosis (scrub typhus). J Med Entomol. 1974 Jul 15;11(3):237–303. doi: 10.1093/jmedent/11.3.237. [DOI] [PubMed] [Google Scholar]
- Walker J. S., Gan E., Chan Teik Chye, Muul I. Involvement of small mammals in the transmission of scrub typhus in Malaysia: isolation and serological evidence. Trans R Soc Trop Med Hyg. 1973;67(6):838–845. doi: 10.1016/0035-9203(73)90012-6. [DOI] [PubMed] [Google Scholar]