Figure 2.

Impact of APOE and Smoking Status on Processing Speed for Patients vs. Controls (A) and by Treatment (B).

Bar plots of the observed average post-treatment processing speed outcomes for cancer patients and non-cancer controls (subplot (A)). The error bars represent the model-predicted 95% confidence intervals. Sample sizes of the subgroups are listed at the bottom of the graphs in parentheses. The interaction between APOE4 status and smoking history is represented with color, in the order as shown, with APOE4 present and a history of smoking represented by dark blue bars, APOE4 present but never smoked (light blue), APOE4 absent and a history of smoking (dark yellow), and APOE4 absent and never smoked (light yellow). Specific statistical contrasts were applied to test, in subplot (A): APOE4 and smoking history within patients (contrast (a)); APOE4 by smoking history interaction within non-cancer controls ((b)); and whether the pattern of the APOE4 by smoking history interaction is significantly different among the patients compared to non-cancer controls ((c)). In subplot (B), the two patient groups were further stratified by cancer treatment.