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. 1977 Apr;16(1):88–92. doi: 10.1128/iai.16.1.88-92.1977

Immunoprophylaxis of experimental Mycoplasma pneumoniae disease: effect of route of administration on the immunogenicity and protective effect of inactivated M. pneumoniae vaccine.

H Greenberg, C M Helms, M B Grizzard, W D James, R L Horswood, R M Chanock
PMCID: PMC421492  PMID: 873618

Abstract

Formalin-inactivated Mycoplasma pneumoniae vaccine was administered subcutaneously or intranasally to hamsters to examine the effect of route of administration on immunogenicity and protective effect. Parenterally administered vaccine in the doses employed induced serum complement-fixing antibody formation, but did not significantly decrease the frequency of pneumonia following challenge with virulent M. pneumoniae. Intranasally instilled vaccine was ineffective in stimulating serum antibody, but did diminish the frequency of experimentally induced pneumonia due to M. pneumoniae. However, a greater degree of resistance was induced by intranasal infection with either wild-type organisms or the ts 640 attenuated mutant of M. pneumoniae.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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