Abstract
A human stool filtrate containing rotavirus which was administered orally to gnotobiotic lambs caused diarrhea, virus excretion, development of antibodies to rotavirus, and pathological changes in the villi of the small intestine. Thus, lambs may serve as experimental animals for the study of human rotavirus infections. This model system was used to study passive protection. Human immunoglobulin G (IgG) containing antibody to rotavirus was fed to lambs 24 to 78 h after birth, and the lambs were infected with lamb-passaged human rotavirus when 30 h old. The lambs treated with IgG did not develop diarrhea, and virus excretion was delayed in onset and shortened in duration. It may be possible to make similar use of IgG to protect children at risk in a rotavirus outbreak. The treatment did not prevent the lambs developing antibody to rotavirus.
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Selected References
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- Bridger J. C., Woode G. N., Jones J. M., Flewett T. H., Bryden A. S., Davies H. Transmission of human rotaviruses to gnotobiotic piglets. J Med Microbiol. 1975 Nov;8(4):565–569. doi: 10.1099/00222615-8-4-565. [DOI] [PubMed] [Google Scholar]
- Davidson G. P., Bishop R. F., Townley R. R., Holmes I. H. Importance of a new virus in acute sporadic enteritis in children. Lancet. 1975 Feb 1;1(7901):242–246. doi: 10.1016/s0140-6736(75)91140-x. [DOI] [PubMed] [Google Scholar]
- Flewett T. H., Bryden A. S., Davies H., Woode G. N., Bridger J. C., Derrick J. M. Relation between viruses from acute gastroenteritis of children and newborn calves. Lancet. 1974 Jul 13;2(7872):61–63. doi: 10.1016/s0140-6736(74)91631-6. [DOI] [PubMed] [Google Scholar]
- Holmes I. H., Mathan M., Bhat P., Albert M. J., Swaminathan S. P., Maiya P. P., Pereira S. M., Baker S. J. Letter: Orbiviruses and gastroenteritis. Lancet. 1974 Sep 14;2(7881):658–659. doi: 10.1016/s0140-6736(74)91987-4. [DOI] [PubMed] [Google Scholar]
- Morris C. A., Flewett T. H., Bryden A. S., Davies H. Epidemic viral enteritis in a long-stay children's ward. Lancet. 1975 Jan 4;1(7897):4–5. doi: 10.1016/s0140-6736(75)92370-3. [DOI] [PubMed] [Google Scholar]
- Snodgrass D. R., Herring J. A., Gray E. W. Experimental rotavirus infection in lambs. J Comp Pathol. 1976 Oct;86(4):637–642. doi: 10.1016/0021-9975(76)90073-6. [DOI] [PubMed] [Google Scholar]
- Snodgrass D. R., Smith W., Gray E. W., Herring J. A. A rotavirus in lambs with diarrhoea. Res Vet Sci. 1976 Jan;20(1):113–114. [PubMed] [Google Scholar]
- Snodgrass D. R., Wells P. W. Rotavirus infection in lambs: studies on passive protection. Arch Virol. 1976;52(3):201–205. doi: 10.1007/BF01348017. [DOI] [PubMed] [Google Scholar]
- Torres-Medina A., Wyatt R. G., Mebus C. A., Underdahl N. R., Kapikian A. Z. Diarrhea caused in gnotobiotic piglets by the reovirus-like agent of human infantile gastroenteritis. J Infect Dis. 1976 Jan;133(1):22–27. doi: 10.1093/infdis/133.1.22. [DOI] [PubMed] [Google Scholar]
- Wyatt R. G., Sly D. L., London W. T., Palmer A. E., Kalica A. R., Van Kirk D. H., Chanock R. M., Kapikian A. Z. Induction of diarrhea in colostrum-deprived newborn rhesus monkeys with the human reovirus-like agent of infantile gastroenteritis. Arch Virol. 1976;50(1-2):17–27. doi: 10.1007/BF01317997. [DOI] [PubMed] [Google Scholar]