Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1977 Apr;16(1):400–402. doi: 10.1128/iai.16.1.400-402.1977

Activation of the alternative complement pathway by Haemophilus influenzae type B.

P H Quinn, F J Crosson Jr, J A Winkelstein, E R Moxon
PMCID: PMC421534  PMID: 301507

Abstract

The results of the following study demonstrate that Haemophilus influenzae type B (HITB) is able to activate the alternative complement pathway. They also demonstrate that the activation of the alternative pathway by HITB is not mediated by the capsule.

Full text

PDF
400

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson P., Johnston R. B., Jr, Smith D. H. Human serum activities against Hemophilus influenzae, type b. J Clin Invest. 1972 Jan;51(1):31–38. doi: 10.1172/JCI106793. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Crosson F. J., Jr, Winkelstein J. A., Moxon E. R. Participation of complement in the nonimmune host defense against experimental Haemophilus influenzae type b septicemia and meningitis. Infect Immun. 1976 Oct;14(4):882–887. doi: 10.1128/iai.14.4.882-887.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Ellman L., Green I., Frank M. Genetically controlled total deficiency of the fourth component of complement in the guinea pig. Science. 1970 Oct 2;170(3953):74–75. doi: 10.1126/science.170.3953.74. [DOI] [PubMed] [Google Scholar]
  4. Gotschlich E. C., Liu T. Y., Artenstein M. S. Human immunity to the meningococcus. 3. Preparation and immunochemical properties of the group A, group B, and group C meningococcal polysaccharides. J Exp Med. 1969 Jun 1;129(6):1349–1365. doi: 10.1084/jem.129.6.1349. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Lew F. T., Yukiyama Y., Waks H. S., Osler A. G. Activation of the alternative (properdin) pathway by divalent cations. J Immunol. 1975 Sep;115(3):884–888. [PubMed] [Google Scholar]
  6. Moxon E. R., Smith A. L., Averill D. R., Smith D. H. Haemophilus influenzae meningitis in infant rats after intranasal inoculation. J Infect Dis. 1974 Feb;129(2):154–162. doi: 10.1093/infdis/129.2.154. [DOI] [PubMed] [Google Scholar]
  7. Ruddy S., Gigli I., Austen K. F. The complement system of man. I. N Engl J Med. 1972 Sep 7;287(10):489–495. doi: 10.1056/NEJM197209072871005. [DOI] [PubMed] [Google Scholar]
  8. Shin H. S., Mayer M. M. The third component of the guinea pig complement system. II. Kinetic study of the reaction of EAC'4,2a with guinea pig C'3. Enzymatic nature of C'3 comsumption, multiphasic character of fixation, and hemolytic titration of C'3. Biochemistry. 1968 Aug;7(8):2997–3002. doi: 10.1021/bi00848a041. [DOI] [PubMed] [Google Scholar]
  9. Winkelstein J. A., Shin H. S., Wood W. B., Jr Heat labile opsonins to Pneumococcus. 3. The participation of immunoglobulin and of the alternate pathway of C3 activation. J Immunol. 1972 Jun;108(6):1681–1689. [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES