We are thankful to Dr. Yeste for the encouraging comments.1 In the previous study, we revealed a specific, SET-initiated, PP2A-mediated, pathway that leads to the increased lyase activity of P450c17 in ovarian theca cells, by which SET regulates testosterone biosynthesis. How to work SET protein in Leydig cells is our new research interesting. Secondly, SET protein is a multifunctional protein involved in histone binding, transcription control, nucleosome assembly, and cell apoptosis. Very interestingly, we found the changing SET expression in the seminiferous epithelium at different stages in this manuscript. The highest level of SET protein was mainly in haploid and tetraploid cells of the prepubertal and adult mice, suggesting that SET is involved in the regulation of the complex, unique process of spermatogenesis. Our group is working on this role of SET protein as you proposed. It will contribute our understanding about molecular mechanism of spermatogenesis.
REFERENCE
- 1.Yeste M. New insights into SET protein during mouse spermatogenesis. Asian J Androl. 2014;16:783. doi: 10.4103/1008-682X.131065. [DOI] [PMC free article] [PubMed] [Google Scholar]