Figure 2.

FVIII activity by one-stage clotting assay showing comparable activity at all dose levels for both rFVIIIFc and Advate®. (a) Advate® 0.8 IU mL⁻¹, rFVIIIFc 0.87 IU mL⁻¹; (b) Advate® 0.2 IU mL⁻¹, rFVIIIFc 0.22 IU mL⁻¹; (c) Advate® 0.05 IU mL⁻¹, rFVIIIFc 0.054 IU mL⁻¹. Box graphs represent median result, 25/75 percentile and minimum/maximum as percentage of label activity. Individual test results (n = 89–90) for each of the three FVIII levels were plotted. FVIII, factor VIII.