Table 3.
Group/binary threshold | Univariate odds ratio | Adjusted* odds ratio | ||||
---|---|---|---|---|---|---|
Odds ratio | 95% CI | P value | Odds ratio | 95% CI | P value | |
All CAD (n = 80), Hsp27 > 2.24 | 0.17 | 0.08-0.34 | 0.0001 | 0.21 | 0.10-0.42 | 0.0001 |
PAD (n = 40), Hsp27 > 2.69 | 0.36 | 0.16-0.81 | 0.013 | 0.25 | 0.09-0.71 | 0.009 |
AAA (n = 80), Hsp27 > 2.75 | 0.43 | 0.22-0.82 | 0.011 | 0.29 | 0.12-0.69 | 0.005 |
All disease patients (n = 200), Hsp27 > 2.63 | 0.32 | 0.18-0.55 | 0.001 | 0.21 | 0.10-0.42 | 0.001 |
PAD & AAA (n = 120), Hsp27 > 2.63 | 0.40 | 0.22-0.72 | 0.002 | 0.26† | 0.17-0.56 | 0.006 |
Logistic regression analysis was used to calculate the odds ratios for having plasma Hsp27 levels above binary thresholds. The reference population was the elderly control group. The adjusted model 1* included age, gender, history of hypertension, dyslipidemia, diabetes, smoking (pack years) and high sensitivity C-reactive protein. Adjusted model 2† included all factors in model 1 plus history of CAD.