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. 1978 Jun;20(3):627–631. doi: 10.1128/iai.20.3.627-631.1978

Enhancement of lymphocyte blastogenic and delayed hypersensitivity skin responses by indomethacin.

C C Muscoplat, P M Rakich, C O Thoen, D W Johnson
PMCID: PMC421904  PMID: 352951

Abstract

Incubation of Mycobacterium bovis-sensitized bovine peripheral blood lymphocytes with concanavalin A or M. bovis purified protein derivative and indomethacin caused a consistent, statistically significant increase in [3H] thymidine uptake as compared to cultures without indomethacin. The kinetics of the response showed that indomethacin must be added to lymphocyte cultures within hours after mitogen or antigen addition for enhancement of [3H]thymidine uptake to occur. Lymphocyte blastogenic responses to purified protein derivative were enhanced in both normal and M. bovis-sensitized lymphocyte cultures. However, enhancement of sensitized lymphocyte responses was significantly (P less than 0.01) greater than that in normal animals. Additionally, indomethacin treatment of M. bovis-sensitized guinea pigs singnificantly augmented delayed skin reactions to tuberculin. Delayed hypersensitive skin reactions were only enhanced when indomethacin was administered simultaneously with tuberculin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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