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. 1978 Jun;20(3):836–841. doi: 10.1128/iai.20.3.836-841.1978

In vitro interaction of alveolar macrophages and pneumocytes with feline respiratory viruses.

J M Langloss, E A Hoover, D E Kahn, A J Kniazeef
PMCID: PMC421933  PMID: 352961

Abstract

Feline alveolar macrophages and feline pneumocytes were inoculated in vitro with low multiplicities of either feline calicivirus or feline viral rhinotracheitis virus. Pneumocytes were permissive for both viruses. High titers were attained, and characteristic cytopathic effects developed. Alveolar macrophages were permissive for feline viral rhinotracheitis virus, although the cycle of replication was delayed. Infection of macrophages with feline calicivirus resulted in the production of viral antigens and cytopathic effects; however, viral particles were not detected by electron microscopy, and viral infectivity titers rose only slightly and then fell to undetectable levels by 96 h. The differences in viral susceptibility between these two peripheral pulmonary cell populations that were demonstrated in vitro probably contribute to the differences in pathogenesis of viral rhinotracheitis and calicivirus infections in cats.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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