TABLE 4 ] .
Airway Pathophysiology Measures: Model-Derived Estimates for Baseline, Posttreatment, Follow-up, and Change From Baseline
| Measure | Mean ± SE | Time Effect P Value | Group × Time Effect P Value | Mean Change (95% CI) From Baseline to | |||||
| Baseline | Post | 1MFU | 6MFU | Post | 1MFU | 6MFU | |||
| FEV1 % predicted | .178 | .833 | |||||||
| CART | 77.7 ± 2.1 | 76.6 ± 2.0 | 74.5 ± 2.3 | 78.2 ± 2.2 | −1.1 (−4.5 to 2.3) | −3.2 (−6.3 to −0.2) | 0.4 (−2.8 to 3.7) | ||
| SLOW | 80.2 ± 2.2 | 80.1 ± 2.1 | 79.0 ± 2.4 | 80.7 ± 2.3 | −0.2 (−3.7 to 3.4) | −1.2 (−4.5 to 2.0) | 0.5 (−3.0 to 4.0) | ||
| Differential change | … | … | … | … | −0.9 (−5.8 to 4.0) | −2.0 (−6.5 to 2.5) | −0.0 (−4.8 to 4.8) | ||
| P value | … | … | … | … | .712 | .383 | .984 | ||
| PEF % predicted | < .001 | .176 | |||||||
| CART | 88.1 ± 2.6 | 89.8 ± 2.5 | 90.5 ± 2.4 | 93.0 ± 2.8 | 1.8 (−1.7 to 5.3) | 2.4 (−1.4 to 6.3) | 5.0 (0.9 to 9.0) | ||
| SLOW | 87.0 ± 2.8 | 94.5 ± 2.7 | 93.6 ± 2.5 | 95.8 ± 3.0 | 7.5 (3.8 to 11.3) | 6.6 (2.5 to 10.6) | 8.8 (4.3 to 13.2) | ||
| Differential change | … | … | … | … | −5.8 (−10.9 to −0.6) | −4.1 (−9.7 to 1.4) | −3.8 (−9.8 to 2.2) | ||
| P value | … | … | … | … | .028 | .144 | .214 | ||
| Feno | .375 | .442 | |||||||
| CART | 43.5 ± 5.6 | 47.5 ± 6.1 | 43.7 ± 5.9 | 37.1 ± 5.4 | 4.1 (−4.9 to 13.1) | 0.3 (−8.8 to 9.3) | −6.4 (−17.4 to 4.5) | ||
| SLOW | 50.5 ± 5.6 | 49.9 ± 6.2 | 51.4 ± 6.2 | 50.2 ± 5.7 | −0.5 (−9.5 to 8.4) | 1.0 (−8.3 to 10.3) | −0.3 (−11.5 to 11.0) | ||
| Differential change | … | … | … | … | 4.6 (−8.0 to 17.2) | −0.7 (−13.7 to 12.3) | −6.1 (−21.9 to −9.6) | ||
| P value | … | … | … | … | .469 | .914 | .439 | ||
| PC20 | |||||||||
| CART | 4.4 ± 0.8 | 6.5 ± 2.3 | … | .013 | .227 | … | 2.1 (−2.1 to 6.4) | … | |
| SLOW | 4.0 ± 0.8 | 10.0 ± 2.6 | … | … | … | … | 6.0 (1.3 to 10.7) | … | |
| Differential change | … | … | … | … | … | … | … | −3.9 (−10.2 to 2.5) | … |
| P value | … | … | … | … | … | … | … | .227 | … |
| PC20 distress | .033 | .049 | |||||||
| CART | 3.5 ± 0.3 | 3.5 ± 0.3 | … | … | 0.0 (−0.8 to 0.9) | … | |||
| SLOW | 2.8 ± 0.3 | 4.0 ± 0.3 | … | … | 1.2 (0.4 to 2.0) | … | |||
| Differential change | … | … | … | … | … | −1.2 (−2.3 to −0.0) | … | ||
| P value | … | … | … | … | … | .049 | … | ||
| PC20 dyspnea | .050 | .973 | |||||||
| CART | 4.4 ± 0.3 | 5.1 0.4 | … | … | 0.7 (−0.3 to 1.7) | … | |||
| SLOW | 4.0 ± 0.3 | 4.7 ± 0.4 | … | … | 0.7 (−0.3 to 1.7) | … | |||
| Differential change | … | … | … | … | … | −0.0 (−1.4 to 1.4) | … | ||
| P value | … | … | … | … | … | .973 | … | ||
Differential change was calculated as the difference from baseline in the CART condition (eg, 1MFU − baseline) minus the difference from baseline for the SLOW condition; higher numbers indicate greater increases in CART vs SLOW. Feno = fraction of exhaled nitric oxide; PC20 = provocation concentration of methacholine leading to a 20% fall in FEV1; PEF = peak expiratory flow. See Table 1 and 2 legends for expansion of other abbreviations.